Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023720562> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2023720562 endingPage "592" @default.
- W2023720562 startingPage "586" @default.
- W2023720562 abstract "The effect of penicillin G on Staphylococcus aureus after phagocytosis by human monocytes was compared with the effect on nonphagocytosed bacteria. Intracellular S. aureus was obtained by incubation of monocytes and preopsonized S. aureus for 3 min at 37 C; phagocytosis was stopped by cooling the test tubes in crushed ice. Nonphagocytosed bacteria were removed by differential centrifugation followed by two washes of the cells. Morphological studies with lysostaphin confirmed the intracellular localization of ∼70% of the bacteria after this procedure. The antibacterial activity of penicillin G was assessed by incubation of monocytes containing ingested S. aureus with the drug at 37 C, and determination of the number of viable cell-associated bacteria was assessed microbiologically at various intervals. Inactivation of the intracellular killing mechanism of the monocytes by omission of serum during incubation allowed measurement of the effect of penicillin G apart from the bactericidal activity of the cells. The effect of penicillin G on nonphagocytosed bacteria was assessed after incubation of preopsonized S. aureus in medium with the drug. The results show that the effect of penicillin G on intracellular S. aureus is two to. seven times stronger than the effect on nonphagocytosed S. aureus." @default.
- W2023720562 created "2016-06-24" @default.
- W2023720562 creator A5035664669 @default.
- W2023720562 creator A5044201005 @default.
- W2023720562 creator A5060463156 @default.
- W2023720562 creator A5076785134 @default.
- W2023720562 date "1986-03-01" @default.
- W2023720562 modified "2023-09-27" @default.
- W2023720562 title "Effect of Penicillin G on Staphylococcus aureus Phagocytosed by Human Monocytes" @default.
- W2023720562 cites W1529589232 @default.
- W2023720562 cites W1560448757 @default.
- W2023720562 cites W1974303883 @default.
- W2023720562 cites W1975829529 @default.
- W2023720562 cites W1994524004 @default.
- W2023720562 cites W2000271455 @default.
- W2023720562 cites W2022119042 @default.
- W2023720562 cites W2024657151 @default.
- W2023720562 cites W2026606228 @default.
- W2023720562 cites W2035586322 @default.
- W2023720562 cites W2052617014 @default.
- W2023720562 cites W2053775486 @default.
- W2023720562 cites W2059065862 @default.
- W2023720562 cites W2081849893 @default.
- W2023720562 cites W2099344083 @default.
- W2023720562 cites W2102179533 @default.
- W2023720562 cites W2113629715 @default.
- W2023720562 cites W2127269372 @default.
- W2023720562 cites W2158647233 @default.
- W2023720562 cites W2168824339 @default.
- W2023720562 cites W2224618827 @default.
- W2023720562 cites W2263419764 @default.
- W2023720562 cites W2266826700 @default.
- W2023720562 cites W2267779849 @default.
- W2023720562 cites W2322381039 @default.
- W2023720562 cites W2400956384 @default.
- W2023720562 cites W2405436386 @default.
- W2023720562 doi "https://doi.org/10.1093/infdis/153.3.586" @default.
- W2023720562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3950442" @default.
- W2023720562 hasPublicationYear "1986" @default.
- W2023720562 type Work @default.
- W2023720562 sameAs 2023720562 @default.
- W2023720562 citedByCount "14" @default.
- W2023720562 crossrefType "journal-article" @default.
- W2023720562 hasAuthorship W2023720562A5035664669 @default.
- W2023720562 hasAuthorship W2023720562A5044201005 @default.
- W2023720562 hasAuthorship W2023720562A5060463156 @default.
- W2023720562 hasAuthorship W2023720562A5076785134 @default.
- W2023720562 hasConcept C143701427 @default.
- W2023720562 hasConcept C160448771 @default.
- W2023720562 hasConcept C174802600 @default.
- W2023720562 hasConcept C185592680 @default.
- W2023720562 hasConcept C25642318 @default.
- W2023720562 hasConcept C2778673385 @default.
- W2023720562 hasConcept C2779489039 @default.
- W2023720562 hasConcept C3019249092 @default.
- W2023720562 hasConcept C501593827 @default.
- W2023720562 hasConcept C523546767 @default.
- W2023720562 hasConcept C54355233 @default.
- W2023720562 hasConcept C55493867 @default.
- W2023720562 hasConcept C79879829 @default.
- W2023720562 hasConcept C86803240 @default.
- W2023720562 hasConcept C89423630 @default.
- W2023720562 hasConceptScore W2023720562C143701427 @default.
- W2023720562 hasConceptScore W2023720562C160448771 @default.
- W2023720562 hasConceptScore W2023720562C174802600 @default.
- W2023720562 hasConceptScore W2023720562C185592680 @default.
- W2023720562 hasConceptScore W2023720562C25642318 @default.
- W2023720562 hasConceptScore W2023720562C2778673385 @default.
- W2023720562 hasConceptScore W2023720562C2779489039 @default.
- W2023720562 hasConceptScore W2023720562C3019249092 @default.
- W2023720562 hasConceptScore W2023720562C501593827 @default.
- W2023720562 hasConceptScore W2023720562C523546767 @default.
- W2023720562 hasConceptScore W2023720562C54355233 @default.
- W2023720562 hasConceptScore W2023720562C55493867 @default.
- W2023720562 hasConceptScore W2023720562C79879829 @default.
- W2023720562 hasConceptScore W2023720562C86803240 @default.
- W2023720562 hasConceptScore W2023720562C89423630 @default.
- W2023720562 hasIssue "3" @default.
- W2023720562 hasLocation W20237205621 @default.
- W2023720562 hasLocation W20237205622 @default.
- W2023720562 hasOpenAccess W2023720562 @default.
- W2023720562 hasPrimaryLocation W20237205621 @default.
- W2023720562 hasRelatedWork W1857130763 @default.
- W2023720562 hasRelatedWork W1887000714 @default.
- W2023720562 hasRelatedWork W2001880697 @default.
- W2023720562 hasRelatedWork W2023720562 @default.
- W2023720562 hasRelatedWork W2026176496 @default.
- W2023720562 hasRelatedWork W2037011719 @default.
- W2023720562 hasRelatedWork W203949208 @default.
- W2023720562 hasRelatedWork W2086845333 @default.
- W2023720562 hasRelatedWork W2152001954 @default.
- W2023720562 hasRelatedWork W253766818 @default.
- W2023720562 hasVolume "153" @default.
- W2023720562 isParatext "false" @default.
- W2023720562 isRetracted "false" @default.
- W2023720562 magId "2023720562" @default.
- W2023720562 workType "article" @default.