Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023721133> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2023721133 endingPage "291" @default.
- W2023721133 startingPage "291" @default.
- W2023721133 abstract "We tested DNA from 15 centrally infected cases of iatrogenic Creutzfeldt-Jakob disease (CJD) (dura mater or corneal homografts and stereotactic EEG electrodes), 11 peripherally infected cases (native human growth hormone or gonadotrophin), and 110 control individuals for the presence of mutations in the chromosome 20 amyloid gene. No patient or control had any of the known pathogenic point or insert mutations found in familial disease, but allelic homozygosity at polymorphic codon 129 was present in all but two (92%) of the 26 patients, compared with 54 (50%) of the 110 controls (<i>p</i> < 0.001). Pooled data from all identified and tested cases of iatrogenic disease yielded a worldwide total of 56 patients, of whom all but four were homozygous at codon 129 (<i>p</i> < 0.001). These findings support the thesis that homozygosity at codon 129 enhances susceptibility to iatrogenic infections of both central and peripheral origin, with evident implications for the population of dura mater homograft and pituitary hormone recipients whose lives have been complicated by the possibility of exposure to the infectious agent of CJD." @default.
- W2023721133 created "2016-06-24" @default.
- W2023721133 creator A5010013306 @default.
- W2023721133 creator A5023670959 @default.
- W2023721133 creator A5026399324 @default.
- W2023721133 creator A5027502794 @default.
- W2023721133 creator A5036511534 @default.
- W2023721133 creator A5036527555 @default.
- W2023721133 creator A5037639600 @default.
- W2023721133 creator A5049666662 @default.
- W2023721133 creator A5051681237 @default.
- W2023721133 creator A5055743905 @default.
- W2023721133 creator A5068226921 @default.
- W2023721133 creator A5076448039 @default.
- W2023721133 creator A5087386244 @default.
- W2023721133 date "1994-02-01" @default.
- W2023721133 modified "2023-09-27" @default.
- W2023721133 title "Iatrogenic Creutzfeldt-Jakob disease: An example of the interplay between ancient genes and modern medicine" @default.
- W2023721133 doi "https://doi.org/10.1212/wnl.44.2.291" @default.
- W2023721133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8309577" @default.
- W2023721133 hasPublicationYear "1994" @default.
- W2023721133 type Work @default.
- W2023721133 sameAs 2023721133 @default.
- W2023721133 citedByCount "142" @default.
- W2023721133 countsByYear W20237211332012 @default.
- W2023721133 countsByYear W20237211332013 @default.
- W2023721133 countsByYear W20237211332014 @default.
- W2023721133 countsByYear W20237211332015 @default.
- W2023721133 countsByYear W20237211332018 @default.
- W2023721133 countsByYear W20237211332020 @default.
- W2023721133 crossrefType "journal-article" @default.
- W2023721133 hasAuthorship W2023721133A5010013306 @default.
- W2023721133 hasAuthorship W2023721133A5023670959 @default.
- W2023721133 hasAuthorship W2023721133A5026399324 @default.
- W2023721133 hasAuthorship W2023721133A5027502794 @default.
- W2023721133 hasAuthorship W2023721133A5036511534 @default.
- W2023721133 hasAuthorship W2023721133A5036527555 @default.
- W2023721133 hasAuthorship W2023721133A5037639600 @default.
- W2023721133 hasAuthorship W2023721133A5049666662 @default.
- W2023721133 hasAuthorship W2023721133A5051681237 @default.
- W2023721133 hasAuthorship W2023721133A5055743905 @default.
- W2023721133 hasAuthorship W2023721133A5068226921 @default.
- W2023721133 hasAuthorship W2023721133A5076448039 @default.
- W2023721133 hasAuthorship W2023721133A5087386244 @default.
- W2023721133 hasConcept C104317684 @default.
- W2023721133 hasConcept C141071460 @default.
- W2023721133 hasConcept C142724271 @default.
- W2023721133 hasConcept C180754005 @default.
- W2023721133 hasConcept C2778987889 @default.
- W2023721133 hasConcept C2779134260 @default.
- W2023721133 hasConcept C2908647359 @default.
- W2023721133 hasConcept C54355233 @default.
- W2023721133 hasConcept C71924100 @default.
- W2023721133 hasConcept C86803240 @default.
- W2023721133 hasConcept C99454951 @default.
- W2023721133 hasConceptScore W2023721133C104317684 @default.
- W2023721133 hasConceptScore W2023721133C141071460 @default.
- W2023721133 hasConceptScore W2023721133C142724271 @default.
- W2023721133 hasConceptScore W2023721133C180754005 @default.
- W2023721133 hasConceptScore W2023721133C2778987889 @default.
- W2023721133 hasConceptScore W2023721133C2779134260 @default.
- W2023721133 hasConceptScore W2023721133C2908647359 @default.
- W2023721133 hasConceptScore W2023721133C54355233 @default.
- W2023721133 hasConceptScore W2023721133C71924100 @default.
- W2023721133 hasConceptScore W2023721133C86803240 @default.
- W2023721133 hasConceptScore W2023721133C99454951 @default.
- W2023721133 hasIssue "2" @default.
- W2023721133 hasLocation W20237211331 @default.
- W2023721133 hasLocation W20237211332 @default.
- W2023721133 hasOpenAccess W2023721133 @default.
- W2023721133 hasPrimaryLocation W20237211331 @default.
- W2023721133 hasRelatedWork W1970327593 @default.
- W2023721133 hasRelatedWork W1988517967 @default.
- W2023721133 hasRelatedWork W2002128513 @default.
- W2023721133 hasRelatedWork W2010403799 @default.
- W2023721133 hasRelatedWork W2057739827 @default.
- W2023721133 hasRelatedWork W2070922469 @default.
- W2023721133 hasRelatedWork W2171277769 @default.
- W2023721133 hasRelatedWork W2223919059 @default.
- W2023721133 hasRelatedWork W3165452661 @default.
- W2023721133 hasRelatedWork W2092874662 @default.
- W2023721133 hasVolume "44" @default.
- W2023721133 isParatext "false" @default.
- W2023721133 isRetracted "false" @default.
- W2023721133 magId "2023721133" @default.
- W2023721133 workType "article" @default.