FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023721865> ?p ?o ?g. }

• W2023721865 endingPage "16196" @default.
• W2023721865 startingPage "16185" @default.
• W2023721865 abstract "ClpP is a conserved serine-protease with two heptameric rings that enclose a large chamber containing the protease active sites. Each ClpP subunit can be divided into a handle region, which mediates ring-ring interactions, and a head domain. ClpP associates with the hexameric ATPases ClpX and ClpA, which can unfold and translocate substrate proteins through the ClpP axial pores into the protease lumen for degradation. We have determined the x-ray structure of Streptococcus pneumoniae ClpP(A153P) at 2.5 A resolution. The structure revealed two novel features of ClpP which are essential for ClpXP and ClpAP functional activities. First, the Ala → Pro mutation disrupts the handle region, resulting in an altered ring-ring dimerization interface, which, in conjunction with biochemical data, demonstrates the unusual plasticity of this region. Second, the structure shows the existence of a flexible N-terminal loop in each ClpP subunit. The loops line the axial pores in the ClpP tetradecamer and then protrude from the protease apical surface. The sequence of the N-terminal loop is highly conserved in ClpP across all kingdoms of life. These loops are essential determinants for complex formation between ClpP and ClpX/ClpA. Mutation of several amino acid residues in this loop or the truncation of the loop impairs ClpXP and ClpAP complex formation and prevents the coupling between ClpX/ClpA and ClpP activities." @default.
• W2023721865 created "2016-06-24" @default.
• W2023721865 creator A5036169027 @default.
• W2023721865 creator A5049506733 @default.
• W2023721865 creator A5051714306 @default.
• W2023721865 creator A5063056320 @default.
• W2023721865 creator A5077991160 @default.
• W2023721865 creator A5083043647 @default.
• W2023721865 date "2005-04-01" @default.
• W2023721865 modified "2023-10-13" @default.
• W2023721865 title "The ClpP Double Ring Tetradecameric Protease Exhibits Plastic Ring-Ring Interactions, and the N Termini of Its Subunits Form Flexible Loops That Are Essential for ClpXP and ClpAP Complex Formation" @default.
• W2023721865 cites W1532942255 @default.
• W2023721865 cites W1539796472 @default.
• W2023721865 cites W1547976855 @default.
• W2023721865 cites W1571361882 @default.
• W2023721865 cites W1590769279 @default.
• W2023721865 cites W1602037468 @default.
• W2023721865 cites W1822881903 @default.
• W2023721865 cites W1897176773 @default.
• W2023721865 cites W1943336505 @default.
• W2023721865 cites W1947552193 @default.
• W2023721865 cites W1973507897 @default.
• W2023721865 cites W1975460230 @default.
• W2023721865 cites W1976782150 @default.
• W2023721865 cites W1980534130 @default.
• W2023721865 cites W1982601581 @default.
• W2023721865 cites W1987262921 @default.
• W2023721865 cites W1995017064 @default.
• W2023721865 cites W1996218556 @default.
• W2023721865 cites W1999119754 @default.
• W2023721865 cites W1999467171 @default.
• W2023721865 cites W2003095772 @default.
• W2023721865 cites W2004747515 @default.
• W2023721865 cites W2007030549 @default.
• W2023721865 cites W2008561447 @default.
• W2023721865 cites W2012563603 @default.
• W2023721865 cites W2014871071 @default.
• W2023721865 cites W2015078576 @default.
• W2023721865 cites W2016800541 @default.
• W2023721865 cites W2022419259 @default.
• W2023721865 cites W2031794174 @default.
• W2023721865 cites W2036127950 @default.
• W2023721865 cites W2037454127 @default.
• W2023721865 cites W2055629216 @default.
• W2023721865 cites W2069602560 @default.
• W2023721865 cites W2085343528 @default.
• W2023721865 cites W2092694844 @default.
• W2023721865 cites W2099196052 @default.
• W2023721865 cites W2100038539 @default.
• W2023721865 cites W2105844209 @default.
• W2023721865 cites W2109545101 @default.
• W2023721865 cites W2128166055 @default.
• W2023721865 cites W2139058438 @default.
• W2023721865 cites W2139739021 @default.
• W2023721865 cites W2142316927 @default.
• W2023721865 cites W2144047169 @default.
• W2023721865 cites W2144468006 @default.
• W2023721865 cites W2145571109 @default.
• W2023721865 cites W2146375963 @default.
• W2023721865 cites W2148853951 @default.
• W2023721865 cites W2152764495 @default.
• W2023721865 cites W2157318559 @default.
• W2023721865 cites W2159465854 @default.
• W2023721865 cites W2161312954 @default.
• W2023721865 cites W2162524966 @default.
• W2023721865 cites W2525818956 @default.
• W2023721865 doi "https://doi.org/10.1074/jbc.m414124200" @default.
• W2023721865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15701650" @default.
• W2023721865 hasPublicationYear "2005" @default.
• W2023721865 type Work @default.
• W2023721865 sameAs 2023721865 @default.
• W2023721865 citedByCount "121" @default.
• W2023721865 countsByYear W20237218652012 @default.
• W2023721865 countsByYear W20237218652013 @default.
• W2023721865 countsByYear W20237218652014 @default.
• W2023721865 countsByYear W20237218652015 @default.
• W2023721865 countsByYear W20237218652016 @default.
• W2023721865 countsByYear W20237218652017 @default.
• W2023721865 countsByYear W20237218652018 @default.
• W2023721865 countsByYear W20237218652019 @default.
• W2023721865 countsByYear W20237218652020 @default.
• W2023721865 countsByYear W20237218652021 @default.
• W2023721865 countsByYear W20237218652022 @default.
• W2023721865 countsByYear W20237218652023 @default.
• W2023721865 crossrefType "journal-article" @default.
• W2023721865 hasAuthorship W2023721865A5036169027 @default.
• W2023721865 hasAuthorship W2023721865A5049506733 @default.
• W2023721865 hasAuthorship W2023721865A5051714306 @default.
• W2023721865 hasAuthorship W2023721865A5063056320 @default.
• W2023721865 hasAuthorship W2023721865A5077991160 @default.
• W2023721865 hasAuthorship W2023721865A5083043647 @default.
• W2023721865 hasBestOaLocation W20237218651 @default.
• W2023721865 hasConcept C12554922 @default.
• W2023721865 hasConcept C178790620 @default.
• W2023721865 hasConcept C181199279 @default.
• W2023721865 hasConcept C185592680 @default.
• W2023721865 hasConcept C2776714187 @default.
• W2023721865 hasConcept C2780378348 @default.

• next