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- W2023723024 abstract "All seven possible bradykinin (BK) analogs contained Aib in place of proline have been synthesized by the solid phase method and assayed for in vitro myotropic activity on the guinea pig ileum and rat uterus, and in vivo on the rat blood pressure, both in intravenous and intra-aortic administration. [Aib(2,3)]-BK, [Aib(2,7)]-BK, and [Aib(2,3,7)]-BK had no in vivo or in vitro activities; [Aib(2)]-BK, [Aib(3)]-BK and [Aib(3,7)]-BK had moderate BK-like activities and a significantly increased resistance to pulmonary inactivation in the rat ([Aib(3,7)]-BK was totally resistant). [Aib(7)]-BK was found to be the most active position seven BK analog yet assayed on the rat blood pressure, and shows remarkably high ileum (4 times BK) and intravenous rat blood pressure (6 times BK) activity." @default.
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- W2023723024 date "1980-09-01" @default.
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- W2023723024 title "Bradykinin analogs containing α-aminoisobutyric acid (Aib)" @default.
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- W2023723024 doi "https://doi.org/10.1016/0196-9781(80)90059-5" @default.
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