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- W2023725364 abstract "Activation of coronary vascular α-adrenoceptors results in vasoconstriction which competes with metabolic vasodilation during sympathetic activation. Epicardial conduit vessel constriction is largely mediated by α1-adrenoceptors; the constriction of the resistive microcirculation largely by α2-adrenoceptors, but also by α1-adrenoceptors. There is no firm evidence that α-adrenergic coronary vasoconstriction exerts a beneficial effect on transmural blood flow distribution. In fact, α-blockade in anesthetized and conscious dogs improves blood flow to all transmural layers, during normoperfusion and hypoperfusion. Also, in patients with coronary artery disease, blockade of α1- and α2-adrenoceptors improves coronary blood flow, myocardial function and metabolism. This article is part of a Special Issue entitled “Coronary Blood Flow”." @default.
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- W2023725364 date "2012-04-01" @default.
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- W2023725364 title "Reprint of: The paradox of α-adrenergic coronary vasoconstriction revisited" @default.
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- W2023725364 doi "https://doi.org/10.1016/j.yjmcc.2011.12.010" @default.
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