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- W2023726073 abstract "When measured within 2 days of a unilateral occlusion of the middle cerebral artery (MCA) combined with tandem occlusion of the ipsilateral common carotid artery in rats, contralateral neurological deficits were detectable, with brain swelling and a consistent degree of neocortical infarction in the ipsilateral hemisphere. Oxypurinol (40 mg/kg i.p. administered 0.5 h prior to, and 24 h after, the onset of focal ischemia) significantly reduced the development of the ischemic infarct (P < 0.001); attenuated tissue swelling (P < 0.01) and ameliorated the neurological deficits (P < 0.05). These findings suggest that this compound may be useful for the prevention or treatment of ischemic brain injuries, such as those occurring during stroke." @default.
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- W2023726073 title "Oxypurinol reduces focal ischemic brain injury in the rat" @default.
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- W2023726073 doi "https://doi.org/10.1016/0304-3940(91)90550-d" @default.
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