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- W2023730860 abstract "The initial step in retroviral infection involves specific interactions between viral envelope proteins (Env) and specific receptors on the surface of target cells. For many years, little was known about the entry receptors for HTLV-1. During this time, however, functional domains of the HTLV-1 Env were identified by analyzing the effects of neutralizing antibodies and specific mutations in Env on HTLV-1 infectivity. More recent studies have revealed that HTLV-1 infectivity involves interactions with three different molecules: heparan sulfate proteoglycans (HSPG), the VEGF-165 receptor Neuropilin 1 (NRP-1) and glucose transporter type 1 (GLUT1). Here, we revisit previously published data on the functional domains of Env in regard to the recent knowledge acquired about this multi-receptor complex. We also discuss the similarities and differences between HTLV-1 and other deltaretroviruses in regards to receptor usage." @default.
- W2023730860 created "2016-06-24" @default.
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- W2023730860 date "2011-06-15" @default.
- W2023730860 modified "2023-10-14" @default.
- W2023730860 title "Molecular Aspects of HTLV-1 Entry: Functional Domains of the HTLV-1 Surface Subunit (SU) and Their Relationships to the Entry Receptors" @default.
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- W2023730860 doi "https://doi.org/10.3390/v3060794" @default.
- W2023730860 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3185769" @default.
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