FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023731023> ?p ?o ?g. }

• W2023731023 endingPage "189" @default.
• W2023731023 startingPage "181" @default.
• W2023731023 abstract "Bioavailability of talinolol, a β₁-adrenergic receptor antagonist, was enhanced by coadministration with grapefruit juice (GFJ) in rats, whereas GFJ ingestion markedly reduced the absorption of talinolol in humans. Because our recent study indicated that the inhibitory effect of GFJ on organic anion-transporting polypeptide (Oatp)- and P-gp-mediated talinolol absorption depends on the concentration of naringin in ingested GFJ, the apparent inconsistent findings may be explained by the species difference in the affinity of naringin for OATP/Oatp and P-gp multidrug resistance 1 (MDR1/Mdr1) between humans and rats. Although human MDR1-mediated talinolol transport was not inhibited by 2000 μM naringin, naringin inhibited human OATP1A2-, rat Oatp1a5-, and rat Mdr1a-mediated talinolol transport with IC₅₀ values of 343, 12.7, and 604 μM, respectively, in LLC-PK1 cell and <i>Xenopus laevis</i> oocyte systems. Because the naringin concentration in commercially prepared GFJ was found to be approximately 1200 μM, these results suggested that GFJ would reduce the intestinal absorption of talinolol through inhibition of OATP1A2-mediated talinolol uptake in humans, whereas an increase of talinolol absorption is mainly through inhibition of Mdr1a-mediated efflux in rats. The rat intestinal permeability of talinolol measured by the in situ closed loop method was indeed significantly increased in the presence of GFJ, whereas a significant decrease was observed with 6-fold diluted GFJ, in which the naringin concentration was approximately 200 μM. The present study indicated that the species difference in the effect of GFJ on intestinal absorption of talinolol between humans and rats may be due to differences in the affinity of naringin for OATP/Oatp and MDR1/Mdr1 transporters between the two species." @default.
• W2023731023 created "2016-06-24" @default.
• W2023731023 creator A5007186343 @default.
• W2023731023 creator A5012870403 @default.
• W2023731023 creator A5026770912 @default.
• W2023731023 creator A5058859139 @default.
• W2023731023 creator A5059075124 @default.
• W2023731023 creator A5061728132 @default.
• W2023731023 date "2009-09-24" @default.
• W2023731023 modified "2023-10-17" @default.
• W2023731023 title "Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol between Human and Rat" @default.
• W2023731023 cites W1971075428 @default.
• W2023731023 cites W1988341201 @default.
• W2023731023 cites W1988551662 @default.
• W2023731023 cites W2002583826 @default.
• W2023731023 cites W2002619956 @default.
• W2023731023 cites W2004424126 @default.
• W2023731023 cites W2005408062 @default.
• W2023731023 cites W2008077160 @default.
• W2023731023 cites W2034006321 @default.
• W2023731023 cites W2034528477 @default.
• W2023731023 cites W2035197369 @default.
• W2023731023 cites W2040879255 @default.
• W2023731023 cites W2041049648 @default.
• W2023731023 cites W2043305969 @default.
• W2023731023 cites W2044113055 @default.
• W2023731023 cites W2044392411 @default.
• W2023731023 cites W2045567622 @default.
• W2023731023 cites W2046877654 @default.
• W2023731023 cites W2046991250 @default.
• W2023731023 cites W2053545020 @default.
• W2023731023 cites W2057826873 @default.
• W2023731023 cites W2060216571 @default.
• W2023731023 cites W2074179782 @default.
• W2023731023 cites W2076491064 @default.
• W2023731023 cites W2080786325 @default.
• W2023731023 cites W2081329598 @default.
• W2023731023 cites W2092661856 @default.
• W2023731023 cites W2110673396 @default.
• W2023731023 cites W2126348132 @default.
• W2023731023 cites W2134431157 @default.
• W2023731023 cites W2141814458 @default.
• W2023731023 cites W2148070209 @default.
• W2023731023 cites W2149878159 @default.
• W2023731023 cites W2150991974 @default.
• W2023731023 cites W2151477936 @default.
• W2023731023 cites W2167979733 @default.
• W2023731023 doi "https://doi.org/10.1124/jpet.109.159756" @default.
• W2023731023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19779132" @default.
• W2023731023 hasPublicationYear "2009" @default.
• W2023731023 type Work @default.
• W2023731023 sameAs 2023731023 @default.
• W2023731023 citedByCount "118" @default.
• W2023731023 countsByYear W20237310232012 @default.
• W2023731023 countsByYear W20237310232013 @default.
• W2023731023 countsByYear W20237310232014 @default.
• W2023731023 countsByYear W20237310232015 @default.
• W2023731023 countsByYear W20237310232016 @default.
• W2023731023 countsByYear W20237310232017 @default.
• W2023731023 countsByYear W20237310232018 @default.
• W2023731023 countsByYear W20237310232019 @default.
• W2023731023 countsByYear W20237310232020 @default.
• W2023731023 countsByYear W20237310232021 @default.
• W2023731023 countsByYear W20237310232022 @default.
• W2023731023 countsByYear W20237310232023 @default.
• W2023731023 crossrefType "journal-article" @default.
• W2023731023 hasAuthorship W2023731023A5007186343 @default.
• W2023731023 hasAuthorship W2023731023A5012870403 @default.
• W2023731023 hasAuthorship W2023731023A5026770912 @default.
• W2023731023 hasAuthorship W2023731023A5058859139 @default.
• W2023731023 hasAuthorship W2023731023A5059075124 @default.
• W2023731023 hasAuthorship W2023731023A5061728132 @default.
• W2023731023 hasConcept C104317684 @default.
• W2023731023 hasConcept C112705442 @default.
• W2023731023 hasConcept C121332964 @default.
• W2023731023 hasConcept C123584848 @default.
• W2023731023 hasConcept C125287762 @default.
• W2023731023 hasConcept C126322002 @default.
• W2023731023 hasConcept C149011108 @default.
• W2023731023 hasConcept C181389837 @default.
• W2023731023 hasConcept C185592680 @default.
• W2023731023 hasConcept C200082930 @default.
• W2023731023 hasConcept C24890656 @default.
• W2023731023 hasConcept C2776678969 @default.
• W2023731023 hasConcept C2776773239 @default.
• W2023731023 hasConcept C2777335409 @default.
• W2023731023 hasConcept C2781071285 @default.
• W2023731023 hasConcept C43617362 @default.
• W2023731023 hasConcept C55493867 @default.
• W2023731023 hasConcept C71924100 @default.
• W2023731023 hasConcept C86803240 @default.
• W2023731023 hasConcept C98274493 @default.
• W2023731023 hasConceptScore W2023731023C104317684 @default.
• W2023731023 hasConceptScore W2023731023C112705442 @default.
• W2023731023 hasConceptScore W2023731023C121332964 @default.
• W2023731023 hasConceptScore W2023731023C123584848 @default.
• W2023731023 hasConceptScore W2023731023C125287762 @default.
• W2023731023 hasConceptScore W2023731023C126322002 @default.

• next