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• W2023732561 startingPage "701" @default.
• W2023732561 abstract "This study examined the effects of daidzin, a major isoflavone from Puerariae Radix, on D-galactosamine (D-GalN) and lipopolysaccharide (LPS)-induced liver failure. Mice were given an intraperitoneal injection of daidzin (25, 50, 100 and 200 mg/kg) 1 h before receiving an injection of D-GalN (700 mg/kg)/LPS (10 microg/kg). Daidzin markedly reduced the elevated serum aminotransferase activity and the levels of lipid peroxidation and tumor necrosis factor-alpha. The glutathione content was lower in the D-GalN/LPS group, which was attenuated by daidzin. The daidzin pretreatment attenuated the swollen mitochondria observed in the d-GalN/LPS group. Daidzin attenuated the apoptosis of hepatocytes, which was confirmed using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method and a caspase-3 assay. Overall, these results suggest that the liver protection of daidzin is due to reduced oxidative stress and its antiapoptotic activity." @default.
• W2023732561 created "2016-06-24" @default.
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• W2023732561 date "2008-12-23" @default.
• W2023732561 modified "2023-09-24" @default.
• W2023732561 title "Protective effect of daidzin against <scp>d</scp> -galactosamine and lipopolysaccharide-induced hepatic failure in mice" @default.
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• W2023732561 doi "https://doi.org/10.1002/ptr.2710" @default.
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