Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023732993> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2023732993 endingPage "58" @default.
- W2023732993 startingPage "29" @default.
- W2023732993 abstract "We report a case of peripheral both demyelinating and axonal polyneuropathy in a patient affected from intestinal aganglionosis with high dose intermittent metronidazole therapy. Intestinal aganglionosis is a myenteric plexus disorder with lack of innervation concerning the whole digestive tract from the rectum to the esophagus. The familial incidence of this condition seems to be high and a recessive autosomal transmission is likely. In the pathogenesis of this disorder aberrant neural crest migration seems to be implicated: indeed frequent neurologic signs resembling dysautonomic ones, deafness and rare peripheral demyelinating or axonal neuropathies are associated. The patient was a 12 years old female child affected by intestinal aganglionosis and underwent to chronic intermittent Metronidazole treatment, with daily doses of 500 mg for 15 day every month. She was admitted to our Hospital for inability to walk, dysesthesias and pain at lower limbs, acutely started and progressively worsening. At the admission neurological examination showed ataxic gait with bilateral foot drop, severe distal weakness, bilateral tibialis anterior muscle atrophy, absent deep tendon reflexes, rapidly worsening. CSF was normal. Antibodies against to peripheral nerve (antigangliosides, sulfatide, MAG, glycosaminoglycans) resulted negative. Spinal cord MRI revealed increased roots size and increased epidural space. EMG showed denervation spontaneous activity with neurogenic MUAP modification on distal muscles. Nerve conduction study showed severe slowing of motor velocity on right and left peroneal nerves with reduced amplitude of CMAP. Sensory conduction was mild slowing on both sural nerves with reduced amplitude of SAP. Metronidazole therapy was discontinued; desametazone, high dose vitamin and intravenous immunoglobulin therapy was established in addition to rehydration and parenteral nutrition. Clinical conditions progressively improved and at two months follow up the girl was able to walk with mild ataxia. The authors emphasize in described case the difficulty to differentiate toxic or vitamin deficiency or autoimmune pathogenesis." @default.
- W2023732993 created "2016-06-24" @default.
- W2023732993 creator A5000948088 @default.
- W2023732993 creator A5006176698 @default.
- W2023732993 creator A5008300681 @default.
- W2023732993 creator A5020575547 @default.
- W2023732993 creator A5081007439 @default.
- W2023732993 date "2003-02-01" @default.
- W2023732993 modified "2023-09-26" @default.
- W2023732993 title "Abstracts of the 8th Meeting of the Italian Peripheral Nerve Study Group: 51" @default.
- W2023732993 doi "https://doi.org/10.1046/j.1529-8027.2003.00051.x" @default.
- W2023732993 hasPublicationYear "2003" @default.
- W2023732993 type Work @default.
- W2023732993 sameAs 2023732993 @default.
- W2023732993 citedByCount "0" @default.
- W2023732993 crossrefType "journal-article" @default.
- W2023732993 hasAuthorship W2023732993A5000948088 @default.
- W2023732993 hasAuthorship W2023732993A5006176698 @default.
- W2023732993 hasAuthorship W2023732993A5008300681 @default.
- W2023732993 hasAuthorship W2023732993A5020575547 @default.
- W2023732993 hasAuthorship W2023732993A5081007439 @default.
- W2023732993 hasConcept C126322002 @default.
- W2023732993 hasConcept C134018914 @default.
- W2023732993 hasConcept C141071460 @default.
- W2023732993 hasConcept C2779901536 @default.
- W2023732993 hasConcept C2780168130 @default.
- W2023732993 hasConcept C2780247198 @default.
- W2023732993 hasConcept C2781172350 @default.
- W2023732993 hasConcept C42219234 @default.
- W2023732993 hasConcept C46762472 @default.
- W2023732993 hasConcept C555293320 @default.
- W2023732993 hasConcept C71924100 @default.
- W2023732993 hasConcept C90924648 @default.
- W2023732993 hasConceptScore W2023732993C126322002 @default.
- W2023732993 hasConceptScore W2023732993C134018914 @default.
- W2023732993 hasConceptScore W2023732993C141071460 @default.
- W2023732993 hasConceptScore W2023732993C2779901536 @default.
- W2023732993 hasConceptScore W2023732993C2780168130 @default.
- W2023732993 hasConceptScore W2023732993C2780247198 @default.
- W2023732993 hasConceptScore W2023732993C2781172350 @default.
- W2023732993 hasConceptScore W2023732993C42219234 @default.
- W2023732993 hasConceptScore W2023732993C46762472 @default.
- W2023732993 hasConceptScore W2023732993C555293320 @default.
- W2023732993 hasConceptScore W2023732993C71924100 @default.
- W2023732993 hasConceptScore W2023732993C90924648 @default.
- W2023732993 hasIssue "1" @default.
- W2023732993 hasLocation W20237329931 @default.
- W2023732993 hasOpenAccess W2023732993 @default.
- W2023732993 hasPrimaryLocation W20237329931 @default.
- W2023732993 hasRelatedWork W1965543753 @default.
- W2023732993 hasRelatedWork W1987378723 @default.
- W2023732993 hasRelatedWork W2027258567 @default.
- W2023732993 hasRelatedWork W2352092485 @default.
- W2023732993 hasRelatedWork W2368782005 @default.
- W2023732993 hasRelatedWork W2394330061 @default.
- W2023732993 hasRelatedWork W2401697196 @default.
- W2023732993 hasRelatedWork W3030576578 @default.
- W2023732993 hasRelatedWork W4252521261 @default.
- W2023732993 hasRelatedWork W4293570334 @default.
- W2023732993 hasVolume "8" @default.
- W2023732993 isParatext "false" @default.
- W2023732993 isRetracted "false" @default.
- W2023732993 magId "2023732993" @default.
- W2023732993 workType "article" @default.