Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023742335> ?p ?o ?g. }
- W2023742335 endingPage "398" @default.
- W2023742335 startingPage "391" @default.
- W2023742335 abstract "ASA (acetylsalicylic acid) is an NSAID (non-steroidal anti-inflammatory drug). ASA has gained attention as a potential chemopreventive and chemotherapeutic agent for several neoplasms. The aim of this study was to analyse the possible antitumoural effects of ASA in two erythroleukaemic cell lines, with or without the MDR (multidrug resistance) phenotype. The mechanism of action of different concentrations of ASA were compared in K562 (non-MDR) and Lucena (MDR) cells by analysing cell viability, apoptosis and necrosis, intracellular ROS (reactive oxygen species) formation and bcl-2, p53 and cox-2 gene expression. ASA inhibited the cellular proliferation or induced toxicity in K562 and Lucena cell lines, irrespective of the MDR phenotype. The ASA treatment provoked death by apoptosis and necrosis in K562 cells and only by necrosis in Lucena cells. ASA also showed antioxidant activity in both cell lines. The bcl-2, p53 and cox-2 genes in both cell lines treated with ASA seem to exhibit different patterns of expression. However, normal lymphocytes treated with the same ASA concentrations were more resistant than tumoral cells. The results of this work show that both cell lines responded to treatment with ASA, demonstrating a possible antitumoral and anti-MDR role for this drug." @default.
- W2023742335 created "2016-06-24" @default.
- W2023742335 creator A5002086542 @default.
- W2023742335 creator A5049469592 @default.
- W2023742335 creator A5051728444 @default.
- W2023742335 creator A5062110265 @default.
- W2023742335 creator A5075512119 @default.
- W2023742335 creator A5081276440 @default.
- W2023742335 creator A5089046565 @default.
- W2023742335 creator A5090394995 @default.
- W2023742335 date "2011-08-05" @default.
- W2023742335 modified "2023-09-30" @default.
- W2023742335 title "Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells" @default.
- W2023742335 cites W1528969230 @default.
- W2023742335 cites W1604608864 @default.
- W2023742335 cites W1626582486 @default.
- W2023742335 cites W1971967721 @default.
- W2023742335 cites W1973097909 @default.
- W2023742335 cites W1976570855 @default.
- W2023742335 cites W1977535902 @default.
- W2023742335 cites W1977782761 @default.
- W2023742335 cites W1988355439 @default.
- W2023742335 cites W1989705838 @default.
- W2023742335 cites W1989775722 @default.
- W2023742335 cites W2012053348 @default.
- W2023742335 cites W2014085232 @default.
- W2023742335 cites W2026213450 @default.
- W2023742335 cites W2026812838 @default.
- W2023742335 cites W2037666720 @default.
- W2023742335 cites W2037689114 @default.
- W2023742335 cites W2037918177 @default.
- W2023742335 cites W2042347547 @default.
- W2023742335 cites W2057359246 @default.
- W2023742335 cites W2061249926 @default.
- W2023742335 cites W2062404026 @default.
- W2023742335 cites W2063582597 @default.
- W2023742335 cites W2064879068 @default.
- W2023742335 cites W2068806248 @default.
- W2023742335 cites W2076149108 @default.
- W2023742335 cites W2080978038 @default.
- W2023742335 cites W2084504186 @default.
- W2023742335 cites W2087972256 @default.
- W2023742335 cites W2093047381 @default.
- W2023742335 cites W2097304897 @default.
- W2023742335 cites W2112396116 @default.
- W2023742335 cites W2118234018 @default.
- W2023742335 cites W2165997736 @default.
- W2023742335 cites W4211230861 @default.
- W2023742335 cites W72250902 @default.
- W2023742335 cites W85529956 @default.
- W2023742335 cites W102984782 @default.
- W2023742335 doi "https://doi.org/10.1042/bsr20100115" @default.
- W2023742335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21361874" @default.
- W2023742335 hasPublicationYear "2011" @default.
- W2023742335 type Work @default.
- W2023742335 sameAs 2023742335 @default.
- W2023742335 citedByCount "10" @default.
- W2023742335 countsByYear W20237423352012 @default.
- W2023742335 countsByYear W20237423352013 @default.
- W2023742335 countsByYear W20237423352014 @default.
- W2023742335 countsByYear W20237423352015 @default.
- W2023742335 countsByYear W20237423352016 @default.
- W2023742335 countsByYear W20237423352018 @default.
- W2023742335 countsByYear W20237423352019 @default.
- W2023742335 countsByYear W20237423352021 @default.
- W2023742335 crossrefType "journal-article" @default.
- W2023742335 hasAuthorship W2023742335A5002086542 @default.
- W2023742335 hasAuthorship W2023742335A5049469592 @default.
- W2023742335 hasAuthorship W2023742335A5051728444 @default.
- W2023742335 hasAuthorship W2023742335A5062110265 @default.
- W2023742335 hasAuthorship W2023742335A5075512119 @default.
- W2023742335 hasAuthorship W2023742335A5081276440 @default.
- W2023742335 hasAuthorship W2023742335A5089046565 @default.
- W2023742335 hasAuthorship W2023742335A5090394995 @default.
- W2023742335 hasBestOaLocation W20237423352 @default.
- W2023742335 hasConcept C104317684 @default.
- W2023742335 hasConcept C114851261 @default.
- W2023742335 hasConcept C127716648 @default.
- W2023742335 hasConcept C133936738 @default.
- W2023742335 hasConcept C1491633281 @default.
- W2023742335 hasConcept C171122931 @default.
- W2023742335 hasConcept C17991360 @default.
- W2023742335 hasConcept C190283241 @default.
- W2023742335 hasConcept C202751555 @default.
- W2023742335 hasConcept C203014093 @default.
- W2023742335 hasConcept C2776120743 @default.
- W2023742335 hasConcept C31573885 @default.
- W2023742335 hasConcept C502942594 @default.
- W2023742335 hasConcept C503630168 @default.
- W2023742335 hasConcept C54355233 @default.
- W2023742335 hasConcept C55493867 @default.
- W2023742335 hasConcept C79879829 @default.
- W2023742335 hasConcept C81885089 @default.
- W2023742335 hasConcept C86803240 @default.
- W2023742335 hasConcept C95444343 @default.
- W2023742335 hasConcept C98274493 @default.
- W2023742335 hasConceptScore W2023742335C104317684 @default.
- W2023742335 hasConceptScore W2023742335C114851261 @default.