FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W20237428> ?p ?o ?g. }

• W20237428 endingPage "390" @default.
• W20237428 startingPage "377" @default.
• W20237428 abstract "The thymus contributes to the regulation of tolerance and the prevention of autoimmunity at many levels. First, auto-reactive CD4+ and CD8+ T cells are clonally deleted during negative selection in the thymus, establishing central tolerance. The unique expression of the AIRE (autoimmune regulator) gene in medullary thymic epithelial cells results in expression of a broad array of tissue-specific antigens. Thymocytes bearing T-cell receptors that bind to these tissuespecific antigens are clonally deleted. This process removes self-reactive T cells from the repertoire before T cells are exported to the periphery. Second, CD4+CD25bright regulatory T cells (Treg) develop in parallel with CD4+ and CD8+ effector T cells in the thymus (,). Unlike T effector cells, Treg fail to be deleted by exposure to tissue antigens during thymic maturation (). After export to the periphery, Treg cells play a critical role in the prevention of autoimmunity, suppression of inflammatory responses, and the modulation of T-cell homeostasis (,). Finally, productive thymopoiesis, in and of itself, may be a factor deterring autoimmunity. The thymus continuously generates stable, resting populations of naïve T cells that maintain the numbers and the diversity of the T-cell repertoire. Under conditions of lymphopenia prolonged by inadequate thymopoiesis, compensatory peripheral expansion of T cells occurs to maintain stable T-cell levels. Under circumstances in which the repertoire is limited, homeostatic proliferation may increase the opportunity for T-cells reactive with self antigens to expand, leading to autoimmune disorders (). In all of these respects, the thymus maintains immunologic tolerance to self. Given the importance of the thymus in control of autoimmunity, the gradual age-dependent decline in thymic cytoarchitecture and thymopoietic productivity may, therefore, contribute to the development of auto-reactivity and loss of self-tolerance." @default.
• W20237428 created "2016-06-24" @default.
• W20237428 creator A5062706815 @default.
• W20237428 creator A5066218992 @default.
• W20237428 date "2007-01-01" @default.
• W20237428 modified "2023-10-14" @default.
• W20237428 title "Thymic Involution" @default.
• W20237428 cites W118686632 @default.
• W20237428 cites W1503157159 @default.
• W20237428 cites W1580217007 @default.
• W20237428 cites W1610483123 @default.
• W20237428 cites W1893260165 @default.
• W20237428 cites W1977066411 @default.
• W20237428 cites W1977387552 @default.
• W20237428 cites W1978410307 @default.
• W20237428 cites W1978564100 @default.
• W20237428 cites W1983271442 @default.
• W20237428 cites W1988181926 @default.
• W20237428 cites W1996445917 @default.
• W20237428 cites W2004708987 @default.
• W20237428 cites W2005176636 @default.
• W20237428 cites W2006981670 @default.
• W20237428 cites W2018703348 @default.
• W20237428 cites W2020778496 @default.
• W20237428 cites W2032311934 @default.
• W20237428 cites W2032372422 @default.
• W20237428 cites W2038915858 @default.
• W20237428 cites W2053842106 @default.
• W20237428 cites W2054934168 @default.
• W20237428 cites W2056018233 @default.
• W20237428 cites W2062142808 @default.
• W20237428 cites W2067263905 @default.
• W20237428 cites W2071112219 @default.
• W20237428 cites W2076879571 @default.
• W20237428 cites W2078659852 @default.
• W20237428 cites W2081100902 @default.
• W20237428 cites W2090642065 @default.
• W20237428 cites W2094911966 @default.
• W20237428 cites W2096632716 @default.
• W20237428 cites W2097191776 @default.
• W20237428 cites W2104207674 @default.
• W20237428 cites W2108238886 @default.
• W20237428 cites W2110289042 @default.
• W20237428 cites W2111346510 @default.
• W20237428 cites W2111653667 @default.
• W20237428 cites W2113448947 @default.
• W20237428 cites W2119019109 @default.
• W20237428 cites W2122879998 @default.
• W20237428 cites W2124295081 @default.
• W20237428 cites W2125701590 @default.
• W20237428 cites W2130098661 @default.
• W20237428 cites W2133997960 @default.
• W20237428 cites W2136510952 @default.
• W20237428 cites W2140916758 @default.
• W20237428 cites W2150244918 @default.
• W20237428 cites W2154124733 @default.
• W20237428 cites W2155848079 @default.
• W20237428 cites W2156560929 @default.
• W20237428 cites W2157089206 @default.
• W20237428 cites W2165664782 @default.
• W20237428 cites W2171114032 @default.
• W20237428 cites W4254835392 @default.
• W20237428 doi "https://doi.org/10.1007/978-1-59745-395-0_24" @default.
• W20237428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17876107" @default.
• W20237428 hasPublicationYear "2007" @default.
• W20237428 type Work @default.
• W20237428 sameAs 20237428 @default.
• W20237428 citedByCount "21" @default.
• W20237428 countsByYear W202374282012 @default.
• W20237428 countsByYear W202374282013 @default.
• W20237428 countsByYear W202374282018 @default.
• W20237428 countsByYear W202374282022 @default.
• W20237428 crossrefType "book-chapter" @default.
• W20237428 hasAuthorship W20237428A5062706815 @default.
• W20237428 hasAuthorship W20237428A5066218992 @default.
• W20237428 hasConcept C147483822 @default.
• W20237428 hasConcept C154317977 @default.
• W20237428 hasConcept C167672396 @default.
• W20237428 hasConcept C19317047 @default.
• W20237428 hasConcept C202751555 @default.
• W20237428 hasConcept C203014093 @default.
• W20237428 hasConcept C2776090121 @default.
• W20237428 hasConcept C2776566471 @default.
• W20237428 hasConcept C2777016536 @default.
• W20237428 hasConcept C2777868816 @default.
• W20237428 hasConcept C2778830056 @default.
• W20237428 hasConcept C2780130043 @default.
• W20237428 hasConcept C51785407 @default.
• W20237428 hasConcept C54355233 @default.
• W20237428 hasConcept C86803240 @default.
• W20237428 hasConcept C8891405 @default.
• W20237428 hasConcept C95444343 @default.
• W20237428 hasConceptScore W20237428C147483822 @default.
• W20237428 hasConceptScore W20237428C154317977 @default.
• W20237428 hasConceptScore W20237428C167672396 @default.
• W20237428 hasConceptScore W20237428C19317047 @default.
• W20237428 hasConceptScore W20237428C202751555 @default.
• W20237428 hasConceptScore W20237428C203014093 @default.

• next