Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023743822> ?p ?o ?g. }
- W2023743822 endingPage "562" @default.
- W2023743822 startingPage "556" @default.
- W2023743822 abstract "Object Toxoplasmic encephalitis (TE), primary central nervous system lymphoma (PCNSL) and progressive multifocal leukoencephalopathy (PML) are major central nervous system (CNS) diseases in patients with acquired immunodeficiency syndrome (AIDS). We assessed the diagnostic value of polymerase chain reaction (PCR) in the detection of DNAs of Toxoplasma gondii (T. gondii), Epstein-Barr virus (EBV) and JC virus (JCV) in the cerebrospinal fluid (CSF). Methods We compared the PCR results with those of pathological findings at autopsy. Patients or Materials The present study included 23 autopsies representing those in whom CSF samples were obtained before death while the patient was hospitalized or at autopsy. Results The threshold levels for PCR detection were 4 tachyzoites of T. gondii, 5-15 genomes of EBV and 10 genomes of JCV. We identified T. gondii DNA in 4 out of 5 autopsy-defined cases of TE, EBV DNA in 5 out of 5 cases with PCNSL, and JCV DNA in 2 out of 2 cases with PML. The specificity of PCR was 100% in TE, 78 % in PCNSL, and 100 % in PML. Conclusion Although the number of cases was relatively small in this study, PCR correctly identified T. gondii DNA in those cases in which PML or PCNSL was the sole clinical diagnosis. Our results indicate that PCR examination of CSF is a clinically useful tool for the diagnosis of focal brain lesions in patients with AIDS.(Internal Medicine 38: 556-562, 1999)" @default.
- W2023743822 created "2016-06-24" @default.
- W2023743822 creator A5008747724 @default.
- W2023743822 creator A5010558852 @default.
- W2023743822 creator A5018411621 @default.
- W2023743822 creator A5029414324 @default.
- W2023743822 creator A5044293886 @default.
- W2023743822 creator A5056761543 @default.
- W2023743822 creator A5062983227 @default.
- W2023743822 creator A5072097342 @default.
- W2023743822 creator A5086312944 @default.
- W2023743822 creator A5090416709 @default.
- W2023743822 date "1999-01-01" @default.
- W2023743822 modified "2023-10-14" @default.
- W2023743822 title "Detection of Toxoplasma gondii, Epstein-Barr Virus, and JC Virus DNAs in the Cerebrospinal Fluid in Acquired Immunodeficiency Syndrome Patients with Focal Central Nervous System Comlications." @default.
- W2023743822 cites W15076310 @default.
- W2023743822 cites W1581853413 @default.
- W2023743822 cites W1586052498 @default.
- W2023743822 cites W1749661954 @default.
- W2023743822 cites W1943099128 @default.
- W2023743822 cites W1971216956 @default.
- W2023743822 cites W1981212164 @default.
- W2023743822 cites W1984961360 @default.
- W2023743822 cites W2008799242 @default.
- W2023743822 cites W2024123205 @default.
- W2023743822 cites W2037997642 @default.
- W2023743822 cites W2040949435 @default.
- W2023743822 cites W2042971904 @default.
- W2023743822 cites W2046105178 @default.
- W2023743822 cites W2047755629 @default.
- W2023743822 cites W2061146080 @default.
- W2023743822 cites W2073188981 @default.
- W2023743822 cites W2076148268 @default.
- W2023743822 cites W2092650453 @default.
- W2023743822 cites W2152374584 @default.
- W2023743822 cites W2313465853 @default.
- W2023743822 cites W2314879238 @default.
- W2023743822 cites W2334959363 @default.
- W2023743822 cites W2414372670 @default.
- W2023743822 cites W2430884233 @default.
- W2023743822 cites W2468733140 @default.
- W2023743822 cites W3025190738 @default.
- W2023743822 doi "https://doi.org/10.2169/internalmedicine.38.556" @default.
- W2023743822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10435361" @default.
- W2023743822 hasPublicationYear "1999" @default.
- W2023743822 type Work @default.
- W2023743822 sameAs 2023743822 @default.
- W2023743822 citedByCount "37" @default.
- W2023743822 countsByYear W20237438222012 @default.
- W2023743822 countsByYear W20237438222013 @default.
- W2023743822 countsByYear W20237438222017 @default.
- W2023743822 countsByYear W20237438222022 @default.
- W2023743822 crossrefType "journal-article" @default.
- W2023743822 hasAuthorship W2023743822A5008747724 @default.
- W2023743822 hasAuthorship W2023743822A5010558852 @default.
- W2023743822 hasAuthorship W2023743822A5018411621 @default.
- W2023743822 hasAuthorship W2023743822A5029414324 @default.
- W2023743822 hasAuthorship W2023743822A5044293886 @default.
- W2023743822 hasAuthorship W2023743822A5056761543 @default.
- W2023743822 hasAuthorship W2023743822A5062983227 @default.
- W2023743822 hasAuthorship W2023743822A5072097342 @default.
- W2023743822 hasAuthorship W2023743822A5086312944 @default.
- W2023743822 hasAuthorship W2023743822A5090416709 @default.
- W2023743822 hasBestOaLocation W20237438221 @default.
- W2023743822 hasConcept C104317684 @default.
- W2023743822 hasConcept C126322002 @default.
- W2023743822 hasConcept C142724271 @default.
- W2023743822 hasConcept C159047783 @default.
- W2023743822 hasConcept C159654299 @default.
- W2023743822 hasConcept C203014093 @default.
- W2023743822 hasConcept C2522874641 @default.
- W2023743822 hasConcept C2778062946 @default.
- W2023743822 hasConcept C2778128430 @default.
- W2023743822 hasConcept C2779150272 @default.
- W2023743822 hasConcept C2779338263 @default.
- W2023743822 hasConcept C2779504383 @default.
- W2023743822 hasConcept C2779651940 @default.
- W2023743822 hasConcept C2780644213 @default.
- W2023743822 hasConcept C2781173314 @default.
- W2023743822 hasConcept C49105822 @default.
- W2023743822 hasConcept C529278444 @default.
- W2023743822 hasConcept C55493867 @default.
- W2023743822 hasConcept C71924100 @default.
- W2023743822 hasConcept C86803240 @default.
- W2023743822 hasConceptScore W2023743822C104317684 @default.
- W2023743822 hasConceptScore W2023743822C126322002 @default.
- W2023743822 hasConceptScore W2023743822C142724271 @default.
- W2023743822 hasConceptScore W2023743822C159047783 @default.
- W2023743822 hasConceptScore W2023743822C159654299 @default.
- W2023743822 hasConceptScore W2023743822C203014093 @default.
- W2023743822 hasConceptScore W2023743822C2522874641 @default.
- W2023743822 hasConceptScore W2023743822C2778062946 @default.
- W2023743822 hasConceptScore W2023743822C2778128430 @default.
- W2023743822 hasConceptScore W2023743822C2779150272 @default.
- W2023743822 hasConceptScore W2023743822C2779338263 @default.
- W2023743822 hasConceptScore W2023743822C2779504383 @default.
- W2023743822 hasConceptScore W2023743822C2779651940 @default.
- W2023743822 hasConceptScore W2023743822C2780644213 @default.