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• W2023745099 abstract "Dysregulation of the hypothalamic–pituitary–adrenal (HPA)-axis is hypothesized to underlie stress-related psychiatric disorders such as post-traumatic stress disorder (PTSD). We aimed to explore whether trauma exposure is associated with alterations in HPA-axis functioning in the absence of lifetime psychiatric morbidity. We included 39 trauma-exposed healthy male subjects (mean age = 47 years; SD = 9.2) and 24 non-exposed healthy male controls (mean age = 47.4 years; SD = 14.5). All subjects were free of lifetime psychopathology. Basal salivary cortisol levels (on two consecutive days) as well as the cortisol and adrenocorticotropic hormone (ACTH) response to the combined dexamethasone/corticotropin releasing hormone (Dex/CRH) challenge test were analyzed using general linear models (GLM) adjusted for body mass index, age and smoking status. A blunted salivary cortisol awakening response was found in the exposed group compared to the non-exposed group (F(1,57) = 5.46, p = .02). Consistent with these findings, salivary diurnal cortisol was lower in the trauma-exposed versus non-exposed group (F(1,57) = 4.04, p = .05). No differences, however, were found between both groups for plasma cortisol or ACTH responses to the Dex/CRH test. Low basal cortisol levels were found in trauma-exposed men, suggesting that HPA-axis alterations in men are associated with trauma exposure during adulthood, also in the absence of psychopathology." @default.
• W2023745099 created "2016-06-24" @default.
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• W2023745099 date "2010-07-01" @default.
• W2023745099 modified "2023-09-23" @default.
• W2023745099 title "Trauma exposure in relation to basal salivary cortisol and the hormone response to the dexamethasone/CRH test in male railway employees without lifetime psychopathology" @default.
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• W2023745099 doi "https://doi.org/10.1016/j.psyneuen.2009.11.012" @default.
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