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• W2023746875 endingPage "12833" @default.
• W2023746875 startingPage "12828" @default.
• W2023746875 abstract "Mycobacterium tuberculosis produces three classes of mycolic acids that differ primarily in the presence and nature of oxygen-containing substituents in the distal portion of the meromycolate branch. The methoxymycolate series has a methoxy group adjacent to a methyl branch, in addition to a cyclopropane in the proximal position. Using the gene for the enzyme that introduces the distal cyclopropane (cma1) as a probe, we have cloned and sequenced a cluster of genes coding for four highly homologous methyl transferases (mma1-4). When introduced into Mycobacterium smegmatis, this gene cluster conferred the ability to synthesize methoxymycolates. By determining the structure of the mycolic acids produced following expression of each of these genes individually and in combination, we have elucidated the biosynthetic steps responsible for the production of the major series of methoxymycolates. The mma4 gene product (MMAS-4) catalyzes an unusual S-adenosyl-L-methionine-dependent transformation of the distal cis-olefin into a secondary alcohol with an adjacent methyl branch. MMAS-3 O-methylates this secondary alcohol to form the corresponding methyl ether, and MMAS-2 introduces a cis-cyclopropane in the proximal position of the methoxy series. The similarity of these reactions and the enzymes that catalyze them suggests that some of the structural diversity of mycolic acids results from different chemical fates of a common cationic intermediate, which in turn results from methyl group addition to an olefinic mycolate precursor." @default.
• W2023746875 created "2016-06-24" @default.
• W2023746875 creator A5018322506 @default.
• W2023746875 creator A5019360674 @default.
• W2023746875 date "1996-11-12" @default.
• W2023746875 modified "2023-09-28" @default.
• W2023746875 title "A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in <i>Mycobacterium tuberculosis</i>" @default.
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• W2023746875 doi "https://doi.org/10.1073/pnas.93.23.12828" @default.
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