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• W2023750497 abstract "Neisseria meningitidis is the leading cause of meningitis and severe sepsis in children and young adults worldwide. 1 Stephens DS Greenwood B Brandtzaeg P Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet. 2007; 369: 2196-2210 Summary Full Text Full Text PDF PubMed Scopus (732) Google Scholar The central pathophysiological event in meningococcal disease is bacteraemia, and patients can display a wide range of clinical symptoms ranging from fulminant sepsis to meningitis. 1 Stephens DS Greenwood B Brandtzaeg P Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet. 2007; 369: 2196-2210 Summary Full Text Full Text PDF PubMed Scopus (732) Google Scholar , 2 McIntyre PB O'Brien KL Greenwood B van de Beek D Impact of vaccines on bacterial meningitis worldwide. Lancet. 2012; (in press). Google Scholar Serogroup B is the main meningococcal serogroup causing disease in high-income countries. 3 Brouwer MC Read RC van de Beek D Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis. Lancet Infect Dis. 2010; 10: 262-274 Summary Full Text Full Text PDF PubMed Scopus (72) Google Scholar In this issue of The Lancet Neurology, Russell Viner and colleagues 4 Viner R Booy R Johnson H et al. Outcomes of invasive meningococcal serogroup B disease in children and adolescents (MOSAIC): a case-control study. Lancet Neurol. 2012; (published online Aug 3.)http://dx.doi.org/10.1016/S1474-4422(12)70180-1 PubMed Google Scholar provide an estimate of disease burden in children surviving serogroup B meningococcal disease. Results of this study 4 Viner R Booy R Johnson H et al. Outcomes of invasive meningococcal serogroup B disease in children and adolescents (MOSAIC): a case-control study. Lancet Neurol. 2012; (published online Aug 3.)http://dx.doi.org/10.1016/S1474-4422(12)70180-1 PubMed Google Scholar not only have important implications for the information given to patients and their care givers, but are also imperative for the decision-making process in health-care policy. Outcomes of invasive meningococcal serogroup B disease in children and adolescents (MOSAIC): a case-control studyMost children survive serogroup B meningococcal disease without major sequelae. However, about a tenth have major disabling deficits and more than a third have one or more deficits in physical, cognitive, and psychological functioning, with the additional burden of memory deficits and executive function problems. These findings should help to guide assessments of new vaccines and suggest that all survivors of serogroup B meningococcal disease should be screened for psychological disorders and cognitive deficits in addition to hearing loss. Full-Text PDF" @default.
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• W2023750497 title "The burden of serogroup B meningococcal disease" @default.
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• W2023750497 doi "https://doi.org/10.1016/s1474-4422(12)70184-9" @default.
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