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• W2023751592 abstract "The envelope glycoprotein of vesicular stomatitis virus (VSV-G) enables viral entry into hosts as distant as insects and vertebrates. Because of its ability to support infection of most, if not all, human cell types VSV-G is used in viral vectors for gene therapy. However, neither the receptor nor any specific host factor for VSV-G has been identified. Here we demonstrate that infection with VSV and innate immunity via Toll-like receptors (TLRs) require a shared component, the endoplasmic reticulum chaperone gp96. Cells without gp96 or with catalytically inactive gp96 do not bind VSV-G. The ubiquitous expression of gp96 is therefore essential for the remarkably broad tropism of VSV-G. Cells deficient in gp96 also lack functional TLRs, which suggests that pathogen-driven pressure for TLR-mediated immunity maintains the broad host range of VSV-G by positively selecting for the ubiquitous expression of gp96." @default.
• W2023751592 created "2016-06-24" @default.
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• W2023751592 date "2010-03-29" @default.
• W2023751592 modified "2023-10-12" @default.
• W2023751592 title "Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus" @default.
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• W2023751592 doi "https://doi.org/10.1073/pnas.0908536107" @default.
• W2023751592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2872420" @default.
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