Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023754316> ?p ?o ?g. }
- W2023754316 endingPage "224" @default.
- W2023754316 startingPage "217" @default.
- W2023754316 abstract "The relative effectiveness of different anions in crystallizing proteins follows a reversed Hofmeister sequence for pH < pI and a direct Hofmeister sequence for pH > pI. The phenomenon has been known almost since Hofmeister's original work but it has not been understood. It is here given a theoretical explanation. Classical electrolyte and double layer theory deals only with electrostatic forces acting between ions and proteins. Hydration and hydration interactions are dealt with usually only in terms of assumed hard core models. But there are, at and above biological salt concentrations, other non-electrostatic (NES) ion-specific forces acting that are ignored in such modeling. Such electrodynamic fluctuation forces are also responsible for ion-specific hydration. These missing forces are variously comprehended under familiar but generally unquantified terms, typically, hydration, hydrogen bonding, π-electron–cation interactions, dipole–dipole, dipole-induced dipole and induced dipole-induced dipole forces and so on. The many important body electrodynamic fluctuation force contributions are accessible from extensions of Lifshitz theory from which, with relevant dielectric susceptibility data on solutions as a function of frequency, the forces can be extracted quantitatively, at least in principle. The classical theories of colloid science that miss such contributions do not account for a whole variety of ion-specific phenomena. Numerical results that include these non-electrostatic forces are given here for model calculations of the force between two model charge-regulated hen-egg-white protein surfaces. The surfaces are chosen to carry the same charge groups and charge density as the protein. What emerges is that for pH < pI (where the anions are counter-ions) the repulsive double layer forces increase in the order NaSCN < NaI < NaCl, while at higher pH > pI (where anions are co-ions) the forces increase in the order NaCl < NaI < NaSCN. This is in excellent agreement with both solubility experiments and experiments using SAXS. The results are also consistent with cation effects observed in protein solutions. Our results may provide some insights into a long-standing problem in solution chemistry and biology." @default.
- W2023754316 created "2016-06-24" @default.
- W2023754316 creator A5001303309 @default.
- W2023754316 creator A5021356911 @default.
- W2023754316 creator A5024297349 @default.
- W2023754316 creator A5055349234 @default.
- W2023754316 creator A5070000416 @default.
- W2023754316 creator A5073279557 @default.
- W2023754316 date "2005-10-01" @default.
- W2023754316 modified "2023-10-11" @default.
- W2023754316 title "Why forces between proteins follow different Hofmeister series for pH above and below pI" @default.
- W2023754316 cites W1551360735 @default.
- W2023754316 cites W1826109820 @default.
- W2023754316 cites W1963691400 @default.
- W2023754316 cites W1967935126 @default.
- W2023754316 cites W1974021330 @default.
- W2023754316 cites W1974044909 @default.
- W2023754316 cites W1978359195 @default.
- W2023754316 cites W1979318581 @default.
- W2023754316 cites W1982873585 @default.
- W2023754316 cites W1984498082 @default.
- W2023754316 cites W1985283282 @default.
- W2023754316 cites W1991163974 @default.
- W2023754316 cites W1992761153 @default.
- W2023754316 cites W1996009737 @default.
- W2023754316 cites W2007798828 @default.
- W2023754316 cites W2017292508 @default.
- W2023754316 cites W2017667041 @default.
- W2023754316 cites W2019865803 @default.
- W2023754316 cites W2021725364 @default.
- W2023754316 cites W2025103902 @default.
- W2023754316 cites W2025364567 @default.
- W2023754316 cites W2025868537 @default.
- W2023754316 cites W2027402805 @default.
- W2023754316 cites W2030300349 @default.
- W2023754316 cites W2038398336 @default.
- W2023754316 cites W2056429109 @default.
- W2023754316 cites W2062415479 @default.
- W2023754316 cites W2064197662 @default.
- W2023754316 cites W2073870395 @default.
- W2023754316 cites W2085939885 @default.
- W2023754316 cites W2089413087 @default.
- W2023754316 cites W2090136325 @default.
- W2023754316 cites W2090831884 @default.
- W2023754316 cites W2092874534 @default.
- W2023754316 cites W2094984789 @default.
- W2023754316 cites W2135964386 @default.
- W2023754316 cites W2167905297 @default.
- W2023754316 cites W3100406469 @default.
- W2023754316 doi "https://doi.org/10.1016/j.bpc.2005.05.010" @default.
- W2023754316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15963625" @default.
- W2023754316 hasPublicationYear "2005" @default.
- W2023754316 type Work @default.
- W2023754316 sameAs 2023754316 @default.
- W2023754316 citedByCount "182" @default.
- W2023754316 countsByYear W20237543162012 @default.
- W2023754316 countsByYear W20237543162013 @default.
- W2023754316 countsByYear W20237543162014 @default.
- W2023754316 countsByYear W20237543162015 @default.
- W2023754316 countsByYear W20237543162016 @default.
- W2023754316 countsByYear W20237543162017 @default.
- W2023754316 countsByYear W20237543162018 @default.
- W2023754316 countsByYear W20237543162019 @default.
- W2023754316 countsByYear W20237543162020 @default.
- W2023754316 countsByYear W20237543162021 @default.
- W2023754316 countsByYear W20237543162022 @default.
- W2023754316 countsByYear W20237543162023 @default.
- W2023754316 crossrefType "journal-article" @default.
- W2023754316 hasAuthorship W2023754316A5001303309 @default.
- W2023754316 hasAuthorship W2023754316A5021356911 @default.
- W2023754316 hasAuthorship W2023754316A5024297349 @default.
- W2023754316 hasAuthorship W2023754316A5055349234 @default.
- W2023754316 hasAuthorship W2023754316A5070000416 @default.
- W2023754316 hasAuthorship W2023754316A5073279557 @default.
- W2023754316 hasConcept C117626034 @default.
- W2023754316 hasConcept C121332964 @default.
- W2023754316 hasConcept C145148216 @default.
- W2023754316 hasConcept C147597530 @default.
- W2023754316 hasConcept C147789679 @default.
- W2023754316 hasConcept C150708132 @default.
- W2023754316 hasConcept C159467904 @default.
- W2023754316 hasConcept C173523689 @default.
- W2023754316 hasConcept C17525397 @default.
- W2023754316 hasConcept C178790620 @default.
- W2023754316 hasConcept C185592680 @default.
- W2023754316 hasConcept C58436429 @default.
- W2023754316 hasConcept C62520636 @default.
- W2023754316 hasConcept C68801617 @default.
- W2023754316 hasConcept C97355855 @default.
- W2023754316 hasConceptScore W2023754316C117626034 @default.
- W2023754316 hasConceptScore W2023754316C121332964 @default.
- W2023754316 hasConceptScore W2023754316C145148216 @default.
- W2023754316 hasConceptScore W2023754316C147597530 @default.
- W2023754316 hasConceptScore W2023754316C147789679 @default.
- W2023754316 hasConceptScore W2023754316C150708132 @default.
- W2023754316 hasConceptScore W2023754316C159467904 @default.
- W2023754316 hasConceptScore W2023754316C173523689 @default.
- W2023754316 hasConceptScore W2023754316C17525397 @default.