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• W2023754572 abstract "Osteoporosis remains a serious potential complication of liver transplantation, although its incidence may be significantly reduced by the use of lower doses of glucocorticoids. Additional factors likely to contribute to its pathogenesis include other immunosuppressive agents, particularly cyclosporin A and FK506, vitamin D insufficiency, secondary hyperparathyroidism, hypogonadism and pre-existing bone disease. Bone density assessment and spinal X-rays should be performed before transplantation to assess subsequent fracture risk and vitamin D and gonadal status assessed. Measures should be taken to optimise bone health prior to transplantation; in those with low bone mineral density and/or previous fragility fracture, prophylaxis against bone loss after transplantation should be considered. Although anti-fracture efficacy has not been established for any agent there is evidence, mainly in patients undergoing other forms of solid organ transplantation, that repeated infusions of pamidronate may be effective in preventing bone loss." @default.
• W2023754572 created "2016-06-24" @default.
• W2023754572 creator A5006203478 @default.
• W2023754572 date "2003-04-01" @default.
• W2023754572 modified "2023-10-14" @default.
• W2023754572 title "Osteoporosis after liver transplantation" @default.
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• W2023754572 doi "https://doi.org/10.1053/jlts.2003.50044" @default.
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