Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023757549> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2023757549 endingPage "41" @default.
- W2023757549 startingPage "36" @default.
- W2023757549 abstract "The acrosome is a secretory vesicle located in the mammalian sperm head. Its main function is to transport hydrolytic enzymes. These enzymes will dissolve the zona pellucid, assisting the sperm in fertilizing the egg. The acrosome is assembled in the haploid spermatid during spermiogenesis, but many of its enzymes are already synthesized in pachytene spermatocytes during the early phase of spermatogenesis. Haploid spermatids have developed unique mechanism(s) to assure the proper localization/orientation of the acrosome, attachment near the nucleus, and the targeting of acrosomal proteins towards this vesicle. During spermiogenesis, these germ cells undergo dramatic transformations in shape and intracellular distribution of organelles, and the configuration of microtubules seems to be involved with each specific step. In this context, it seems microtubules are essential for the assembly and formation of the acrosome during spermiogenesis. Microtubules are also involved in guiding proteins to the acrosome, since genetic mouse models with abnormal spermatozoa as their only phenotype were shown to have alterations of the microtubule configuration in round and elongating spermatids, while their spermatozoa were having misplacement of acrosomal proteins. A few genetic mouse models have been designed to study vesicular trafficking or acrosome assembly, and some of these models closely resemble specific human fertility pathologies such as oligoasthenospermia or acrosomeless round-headed sperm. Thus, the study of acrosome biogenesis could aid the development of new infertility tests or the discovery of new regulation targets of sperm production. Keywords: Spermatogenesis, cytoskeleton, spermatid, acrosome" @default.
- W2023757549 created "2016-06-24" @default.
- W2023757549 creator A5003756253 @default.
- W2023757549 creator A5017232819 @default.
- W2023757549 creator A5029431628 @default.
- W2023757549 creator A5077022677 @default.
- W2023757549 creator A5081459114 @default.
- W2023757549 date "2008-03-01" @default.
- W2023757549 modified "2023-09-27" @default.
- W2023757549 title "Microtubule Configuration and Its Relationship to Sperm Morphology in Mammalian Spermiogenesis" @default.
- W2023757549 doi "https://doi.org/10.2174/187152208783790732" @default.
- W2023757549 hasPublicationYear "2008" @default.
- W2023757549 type Work @default.
- W2023757549 sameAs 2023757549 @default.
- W2023757549 citedByCount "1" @default.
- W2023757549 crossrefType "journal-article" @default.
- W2023757549 hasAuthorship W2023757549A5003756253 @default.
- W2023757549 hasAuthorship W2023757549A5017232819 @default.
- W2023757549 hasAuthorship W2023757549A5029431628 @default.
- W2023757549 hasAuthorship W2023757549A5077022677 @default.
- W2023757549 hasAuthorship W2023757549A5081459114 @default.
- W2023757549 hasConcept C123765429 @default.
- W2023757549 hasConcept C134018914 @default.
- W2023757549 hasConcept C20418707 @default.
- W2023757549 hasConcept C2777394357 @default.
- W2023757549 hasConcept C2778252442 @default.
- W2023757549 hasConcept C2778619154 @default.
- W2023757549 hasConcept C2781087480 @default.
- W2023757549 hasConcept C54355233 @default.
- W2023757549 hasConcept C86803240 @default.
- W2023757549 hasConcept C95444343 @default.
- W2023757549 hasConceptScore W2023757549C123765429 @default.
- W2023757549 hasConceptScore W2023757549C134018914 @default.
- W2023757549 hasConceptScore W2023757549C20418707 @default.
- W2023757549 hasConceptScore W2023757549C2777394357 @default.
- W2023757549 hasConceptScore W2023757549C2778252442 @default.
- W2023757549 hasConceptScore W2023757549C2778619154 @default.
- W2023757549 hasConceptScore W2023757549C2781087480 @default.
- W2023757549 hasConceptScore W2023757549C54355233 @default.
- W2023757549 hasConceptScore W2023757549C86803240 @default.
- W2023757549 hasConceptScore W2023757549C95444343 @default.
- W2023757549 hasIssue "1" @default.
- W2023757549 hasLocation W20237575491 @default.
- W2023757549 hasOpenAccess W2023757549 @default.
- W2023757549 hasPrimaryLocation W20237575491 @default.
- W2023757549 hasRelatedWork W1496854728 @default.
- W2023757549 hasRelatedWork W1877865756 @default.
- W2023757549 hasRelatedWork W1971018368 @default.
- W2023757549 hasRelatedWork W2014741807 @default.
- W2023757549 hasRelatedWork W2023757549 @default.
- W2023757549 hasRelatedWork W2031860536 @default.
- W2023757549 hasRelatedWork W2103274446 @default.
- W2023757549 hasRelatedWork W2371052659 @default.
- W2023757549 hasRelatedWork W2375020495 @default.
- W2023757549 hasRelatedWork W2384110748 @default.
- W2023757549 hasVolume "8" @default.
- W2023757549 isParatext "false" @default.
- W2023757549 isRetracted "false" @default.
- W2023757549 magId "2023757549" @default.
- W2023757549 workType "article" @default.