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- W2023758317 abstract "Transition metal contamination poses a serious environmental and human health threat. The bioavailability of transition metals in environmental samples can best be assessed with living organisms. A transgenic strain of the free-living soil nematode Caenorhabditis elegans has been engineered for monitoring the bioavailability of metals. A reporter transgene consisting of a fragment of the promoter from the C. elegans metallothionein-2 gene (mtl-2) that controls the transcription of a β-galactosidase reporter (lacZ) has been integrated into the genome of this organism. By using these transgenic C. elegans, the toxicological response to metals in samples can be quickly measured with a simple histochemical staining assay. The C. elegans that contain the mtl-2:lacZ transgene provide a more sensitive assay of exposure to cadmium, mercury, zinc, and nickel than 24-h LC50 assays or those using nematodes with heat-shock protein–based reporter transgenes. This study demonstrates that C. elegans that contain mtl-2:lacZ transgenes can function as sensitive toxicological indicators of metals." @default.
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- W2023758317 date "2000-01-01" @default.
- W2023758317 modified "2023-09-27" @default.
- W2023758317 title "TRANSGENIC STRAINS OF THE NEMATODE CAENORHABDITIS ELEGANS AS BIOMONITORS OF METAL CONTAMINATION" @default.
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- W2023758317 doi "https://doi.org/10.1897/1551-5028(2000)019<2122:tsotnc>2.3.co;2" @default.
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