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- W2023759172 abstract "The bradycardia evoked by electrical stimulation of the peripheral cut end of the rabbit vagus nerve is mediated by both myelinated and non-myelinated fibres. The purpose of this study was to assess the effects of non-myelinated fibres on heart rate in the rabbit using selective electrical stimulation techniques. In 8 rabbits selective activation of non-myelinated fibres using reversed polarity triangular shaped pulses (10 Hz, 20 s), resulted in a slowly developing fall in heart rate of 24.1 ± 1.1 beats/min which outlasted the period of stimulation by 58.4 ± 4.2 s. In 4 rabbits stimulation of myelinated fibres at 10 Hz for 20 s resulted in a fall in heart rate of 24.5 ± 2.6 beats/min. On stimulation of both myelinated and non-myelinated fibres heart rate fell by 39.9 ± 3.2 beats/min. Heart rate returned rapidly to control value following stimulation of myelinated fibres (5.6 ± 0.5 s) but only slowly after stimulation of both myelinated and non-myelinated fibres (56.7 ± 4.9 s). Atropine (5 mg/kg, i.v.) abolished all effects of vagal stimulation on heart rate. Hexamethonium (15 mg/kg, i.v.) abolished the effect of myelinated fibres on heart rate but did not affect the fall in heart rate produced by non-myelinated fibres. We suggest that the prolonged effects on stimulation of non-myelinated fibres may reflect the persistent action of a non-cholinergic excitatory transmitter at the cardiac parasympathetic ganglia." @default.
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- W2023759172 date "1987-12-01" @default.
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- W2023759172 title "The effect of selective electrical stimulation of non-myelinated vagal fibres on heart rate in the rabbit" @default.
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- W2023759172 doi "https://doi.org/10.1016/0165-1838(87)90024-5" @default.
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