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• W2023760000 abstract "The bioactive lipid sphingosine 1-phosphate (S1P) and its G protein-coupled receptors play critical roles in cardiovascular, immunological, and neural development and function [1Liu Y. Wada R. Yamashita T. Mi Y. Deng C.X. Hobson J.P. Rosenfeldt H.M. Nava V.E. Chae S.S. Lee M.J. et al.Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.J. Clin. Invest. 2000; 106: 951-961Crossref PubMed Scopus (990) Google Scholar, 2Chun J. Lysophospholipids in the nervous system.Prostaglandins Other Lipid Mediat. 2005; 77: 46-51Crossref PubMed Scopus (46) Google Scholar, 3Sanna M.G. Liao J. Jo E. Alfonso C. Ahn M.Y. Peterson M.S. Webb B. Lefebvre S. Chun J. Gray N. Rosen H. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.J. Biol. Chem. 2004; 279: 13839-13848Crossref PubMed Scopus (537) Google Scholar, 4Wendler C.C. Rivkees S.A. Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development.Dev. Biol. 2006; 291: 264-277Crossref PubMed Scopus (41) Google Scholar, 5Kupperman E. An S. Osborne N. Waldron S. Stainier D.Y. A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development.Nature. 2000; 406: 192-195Crossref PubMed Scopus (345) Google Scholar, 6Chiba K. Yanagawa Y. Masubuchi Y. Kataoka H. Kawaguchi T. Ohtsuki M. Hoshino Y. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing.J. Immunol. 1998; 160: 5037-5044PubMed Google Scholar]. Despite its importance, many questions remain about S1P signaling, including how S1P, which is synthesized intracellularly, is released from cells. Mutations in the zebrafish gene encoding the S1P receptor Miles Apart (Mil)/S1P2 disrupt the formation of the primitive heart tube [5Kupperman E. An S. Osborne N. Waldron S. Stainier D.Y. A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development.Nature. 2000; 406: 192-195Crossref PubMed Scopus (345) Google Scholar]. We find that mutations of another zebrafish locus, two of hearts (toh), cause phenotypes that are morphologically indistinguishable from those seen in mil/s1p2 mutants. Positional cloning of toh reveals that it encodes a member of the Spinster-like family of putative transmembrane transporters. The biological functions of these proteins are poorly understood, although phenotypes of the Drosophila spinster and zebrafish not really started mutants suggest that these proteins may play a role in lipid trafficking [7Sweeney S.T. Davis G.W. Unrestricted synaptic growth in spinster-a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation.Neuron. 2002; 36: 403-416Abstract Full Text Full Text PDF PubMed Scopus (214) Google Scholar, 8Kishi S. Bayliss P.E. Uchiyama J. Koshimizu E. Qi J. Nanjappa P. Imamura S. Islam A. Neuberg D. Amsterdam A. Roberts T.M. The identification of zebrafish mutants showing alterations in senescence-associated biomarkers.PLoS Genet. 2008; 4: e1000152Crossref PubMed Scopus (111) Google Scholar]. Through gain- and loss-of-function analyses, we show that toh is required for signaling by S1P2. Further evidence indicates that Toh is involved in the trafficking or cellular release of S1P." @default.
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• W2023760000 date "2008-12-01" @default.
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• W2023760000 title "The Spinster Homolog, Two of Hearts, Is Required for Sphingosine 1-Phosphate Signaling in Zebrafish" @default.
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• W2023760000 doi "https://doi.org/10.1016/j.cub.2008.10.061" @default.
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