FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023761610> ?p ?o ?g. }

• W2023761610 endingPage "435" @default.
• W2023761610 startingPage "430" @default.
• W2023761610 abstract "Objectives The aim of this study was to evaluate the suitability of in vivo x-ray dark-field radiography for early-stage diagnosis of pulmonary emphysema in mice. Furthermore, we aimed to analyze how the dark-field signal correlates with morphological changes of lung architecture at distinct stages of emphysema. Materials and Methods Female 8- to 10-week-old C57Bl/6N mice were used throughout all experiments. Pulmonary emphysema was induced by orotracheal injection of porcine pancreatic elastase (80-U/kg body weight) (n = 30). Control mice (n = 11) received orotracheal injection of phosphate-buffered saline. To monitor the temporal patterns of emphysema development over time, the mice were imaged 7, 14, or 21 days after the application of elastase or phosphate-buffered saline. X-ray transmission and dark-field images were acquired with a prototype grating-based small-animal scanner. In vivo pulmonary function tests were performed before killing the animals. In addition, lungs were obtained for detailed histopathological analysis, including mean cord length (MCL) quantification as a parameter for the assessment of emphysema. Three blinded readers, all of them experienced radiologists and familiar with dark-field imaging, were asked to grade the severity of emphysema for both dark-field and transmission images. Results Histopathology and MCL quantification confirmed the introduction of different stages of emphysema, which could be clearly visualized and differentiated on the dark-field radiograms, whereas early stages were not detected on transmission images. The correlation between MCL and dark-field signal intensities (r = 0.85) was significantly higher than the correlation between MCL and transmission signal intensities (r = 0.37). The readers’ visual ratings for dark-field images correlated significantly better with MCL (r = 0.85) than visual ratings for transmission images (r = 0.36). Interreader agreement and the diagnostic accuracy of both quantitative and visual assessment were significantly higher for dark-field imaging than those for conventional transmission images. Conclusions X-ray dark-field radiography can reliably visualize different stages of emphysema in vivo and demonstrates significantly higher diagnostic accuracy for early stages of emphysema than conventional attenuation-based radiography." @default.
• W2023761610 created "2016-06-24" @default.
• W2023761610 creator A5004673726 @default.
• W2023761610 creator A5009672774 @default.
• W2023761610 creator A5010123699 @default.
• W2023761610 creator A5011186852 @default.
• W2023761610 creator A5022885146 @default.
• W2023761610 creator A5025814507 @default.
• W2023761610 creator A5027548979 @default.
• W2023761610 creator A5028448361 @default.
• W2023761610 creator A5032266841 @default.
• W2023761610 creator A5040377104 @default.
• W2023761610 creator A5043426343 @default.
• W2023761610 creator A5050701650 @default.
• W2023761610 creator A5076400367 @default.
• W2023761610 creator A5079196412 @default.
• W2023761610 date "2015-07-01" @default.
• W2023761610 modified "2023-10-10" @default.
• W2023761610 title "In Vivo Dark-Field Radiography for Early Diagnosis and Staging of Pulmonary Emphysema" @default.
• W2023761610 cites W1607218881 @default.
• W2023761610 cites W1963492502 @default.
• W2023761610 cites W1965411213 @default.
• W2023761610 cites W1968510299 @default.
• W2023761610 cites W1968773425 @default.
• W2023761610 cites W1981037437 @default.
• W2023761610 cites W1987337673 @default.
• W2023761610 cites W1996510359 @default.
• W2023761610 cites W2004687452 @default.
• W2023761610 cites W2016169270 @default.
• W2023761610 cites W2017801689 @default.
• W2023761610 cites W2018575045 @default.
• W2023761610 cites W2020068125 @default.
• W2023761610 cites W2027781395 @default.
• W2023761610 cites W2037483374 @default.
• W2023761610 cites W2057362487 @default.
• W2023761610 cites W2058595825 @default.
• W2023761610 cites W2077318936 @default.
• W2023761610 cites W2092491035 @default.
• W2023761610 cites W2101321813 @default.
• W2023761610 cites W2107449292 @default.
• W2023761610 cites W2108306103 @default.
• W2023761610 cites W2119673679 @default.
• W2023761610 cites W2139336764 @default.
• W2023761610 cites W2145341186 @default.
• W2023761610 cites W2162457045 @default.
• W2023761610 cites W2168366932 @default.
• W2023761610 cites W2328176404 @default.
• W2023761610 cites W5202401 @default.
• W2023761610 doi "https://doi.org/10.1097/rli.0000000000000147" @default.
• W2023761610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25761095" @default.
• W2023761610 hasPublicationYear "2015" @default.
• W2023761610 type Work @default.
• W2023761610 sameAs 2023761610 @default.
• W2023761610 citedByCount "73" @default.
• W2023761610 countsByYear W20237616102015 @default.
• W2023761610 countsByYear W20237616102016 @default.
• W2023761610 countsByYear W20237616102017 @default.
• W2023761610 countsByYear W20237616102018 @default.
• W2023761610 countsByYear W20237616102019 @default.
• W2023761610 countsByYear W20237616102020 @default.
• W2023761610 countsByYear W20237616102021 @default.
• W2023761610 countsByYear W20237616102022 @default.
• W2023761610 countsByYear W20237616102023 @default.
• W2023761610 crossrefType "journal-article" @default.
• W2023761610 hasAuthorship W2023761610A5004673726 @default.
• W2023761610 hasAuthorship W2023761610A5009672774 @default.
• W2023761610 hasAuthorship W2023761610A5010123699 @default.
• W2023761610 hasAuthorship W2023761610A5011186852 @default.
• W2023761610 hasAuthorship W2023761610A5022885146 @default.
• W2023761610 hasAuthorship W2023761610A5025814507 @default.
• W2023761610 hasAuthorship W2023761610A5027548979 @default.
• W2023761610 hasAuthorship W2023761610A5028448361 @default.
• W2023761610 hasAuthorship W2023761610A5032266841 @default.
• W2023761610 hasAuthorship W2023761610A5040377104 @default.
• W2023761610 hasAuthorship W2023761610A5043426343 @default.
• W2023761610 hasAuthorship W2023761610A5050701650 @default.
• W2023761610 hasAuthorship W2023761610A5076400367 @default.
• W2023761610 hasAuthorship W2023761610A5079196412 @default.
• W2023761610 hasConcept C126322002 @default.
• W2023761610 hasConcept C126838900 @default.
• W2023761610 hasConcept C142724271 @default.
• W2023761610 hasConcept C146357865 @default.
• W2023761610 hasConcept C147080431 @default.
• W2023761610 hasConcept C150903083 @default.
• W2023761610 hasConcept C151730666 @default.
• W2023761610 hasConcept C207001950 @default.
• W2023761610 hasConcept C2777397205 @default.
• W2023761610 hasConcept C2777714996 @default.
• W2023761610 hasConcept C2780559512 @default.
• W2023761610 hasConcept C2781244666 @default.
• W2023761610 hasConcept C2989005 @default.
• W2023761610 hasConcept C2992836489 @default.
• W2023761610 hasConcept C36454342 @default.
• W2023761610 hasConcept C53120450 @default.
• W2023761610 hasConcept C544855455 @default.
• W2023761610 hasConcept C71924100 @default.
• W2023761610 hasConcept C75603125 @default.
• W2023761610 hasConcept C86803240 @default.

• next