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• W2023763256 abstract "• Most components of the innate immune system have a pre-metazoan origin. • Injury-induced immune responses are active in non-bilaterian animal species. • Hydra regeneration requires wound closure, cell migration, engulfment of cell debris. • ROS signaling and cytoprotective genes are immediately upregulated in Hydra . • The transcription factors Jun, Fos, Nrf, ATF1/CREB, C/EBP, are pulse up-regulated. The impact of injury-induced immune responses on animal regenerative processes is highly variable, positive or negative depending on the context. This likely reflects the complexity of the innate immune system that behaves as a sentinel in the transition from injury to regeneration. Early-branching invertebrates with high regenerative potential as Hydra provide a unique framework to dissect how injury-induced immune responses impact regeneration. A series of early cellular events likely require an efficient immune response after amputation, as antimicrobial defence, epithelial cell stretching for wound closure, migration of interstitial progenitors toward the wound, cell death, phagocytosis of cell debris, or reconstruction of the extracellular matrix. The analysis of the injury-induced transcriptomic modulations of 2636 genes annotated as immune genes in Hydra identified 43 genes showing an immediate/early pulse regulation in all regenerative contexts examined. These regulations point to an enhanced cytoprotection via ROS signaling ( Nrf , C/EBP , p62/SQSMT1-l2 ), TNFR and TLR signaling ( TNFR16-like , TRAF2l , TRAF5l , jun , fos-related , SIK2 , ATF1/CREB , LRRC28 , LRRC40 , LRRK2 ), proteasomal activity ( p62/SQSMT1-l1 , Ced6/Gulf , NEDD8-conjugating enzyme Ubc12 ), stress proteins ( CRYAB1 , CRYAB2 , HSP16.2 , DnaJB9 , HSP90a1 ), all potentially regulating NF-κB activity. Other genes encoding immune-annotated proteins such as NPYR4, GTPases, Swap70, the antiproliferative BTG1, enzymes involved in lipid metabolism (5-lipoxygenase, ACSF4), secreted clotting factors, secreted peptidases are also pulse regulated upon bisection. By contrast, metalloproteinases and antimicrobial peptide genes largely follow a context-dependent regulation, whereas the protease inhibitor α2macroglobulin gene exhibits a sustained up-regulation. Hence a complex immune response to injury is linked to wound healing and regeneration in Hydra ." @default.
• W2023763256 created "2016-06-24" @default.
• W2023763256 creator A5020409618 @default.
• W2023763256 creator A5021698864 @default.
• W2023763256 creator A5033586886 @default.
• W2023763256 creator A5058758614 @default.
• W2023763256 date "2014-08-01" @default.
• W2023763256 modified "2023-09-24" @default.
• W2023763256 title "Injury-induced immune responses in Hydra" @default.
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