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- W2023763822 endingPage "805" @default.
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- W2023763822 abstract "Type-2 diabetes mellitus (DM-2) is a conformational disease involving intrinsically disordered islet amyloid polypeptide (IAPP), in which a structural transition from physiological polypeptide to pathological deposits takes place. Different factors acquired or inherited, contribute to endoplasmic reticulum stress and/or impair mitochondrial function which leads to conformational changes in IAPP intermediates and ultimately produces oligomers of an anti-parallel crossed β-pleated sheets that eventually accumulate as space-occupying lesions within the islets. Clusters of IAPP monomers form a pore which is linked to channel-like behavior in planar bilayers, indicating that these oligomeric IAPP pores could become incorporated into membranes and alter its barrier properties. Identification of nucleating residues and the residues responsible for this oligomeric tendency could improve understanding of structure–function relationships as well as the molecular mechanism of folding and aggregation of IAPP contributing to the onset of DM-2. A combination of biological, chemical or physical approaches is required to be extensively pursued for the development of a successful anti-amyloidogenic agent to prevent this malady. Exploring the hypothesis of π-stacking may be a better option to control IAPP aggregation if researchers go through the mechanism of π–π interaction, which provides entropy driven energy and direction for self-assembly to control amyloidogenic aggregation." @default.
- W2023763822 created "2016-06-24" @default.
- W2023763822 creator A5037659082 @default.
- W2023763822 creator A5038188486 @default.
- W2023763822 creator A5064323452 @default.
- W2023763822 creator A5077482841 @default.
- W2023763822 creator A5078619617 @default.
- W2023763822 creator A5089862503 @default.
- W2023763822 date "2011-05-01" @default.
- W2023763822 modified "2023-09-26" @default.
- W2023763822 title "A mechanistic approach for islet amyloid polypeptide aggregation to develop anti-amyloidogenic agents for type-2 diabetes" @default.
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