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• W2023765664 abstract "The role of Ca2+ in mediating effects of insulin on skeletal muscle has been widely debated. It is believed that in skeletal muscle Ca2+ has a permissive role, necessary but not of prime importance in mediating the stimulatory actions of insulin. In this review, we present evidence that insulin causes a localized increase in the concentration of Ca2+. Specifically, insulin induces a rise in near-membrane Ca2+ but not the bulk Ca2+ in the myoplasm. The rise in near-membrane Ca2+ is because of an influx through channels that can be blocked by L-type Ca2+ channel inhibitors. Calcium appears to exert some of its subsequent effects via calmodulin-dependent processes as calmodulin inhibitors block the translocation of glucose transporters and other enzymes as well as the insulin-stimulated increase in glucose transport." @default.
• W2023765664 created "2016-06-24" @default.
• W2023765664 creator A5051775398 @default.
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• W2023765664 date "2001-03-01" @default.
• W2023765664 modified "2023-09-30" @default.
• W2023765664 title "The role of Ca²⁺and calmodulin in insulin signalling in mammalian skeletal muscle" @default.
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• W2023765664 doi "https://doi.org/10.1046/j.1365-201x.2001.00828.x" @default.
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