Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023766424> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2023766424 endingPage "158" @default.
- W2023766424 startingPage "155" @default.
- W2023766424 abstract "There have been many reports that P-glycoprotein expression and activity are altered during sepsis, but few of them have examined such changes over 72 h. In this study, we examined the effect of lipopolysaccharide (LPS, 5 mg/kg, ip) on P-glycoprotein expression (Western blotting) and activity (rhodamine-123 (Rho123) pharmacokinetics) in liver and kidneys for 7 days. On day 1 after LPS administration, hepatic P-glycoprotein expression and activity significantly decreased. On day 3, hepatic P-glycoprotein expression significantly increased compared with the control group, while activity had returned to the control level. On day 7, hepatic P-glycoprotein expression returned to the control level. There were no significant changes in P-glycoprotein expression or activity in the kidneys after LPS administration. The amount of Rho123 excretion in urine remained unchanged with (4.2%) or without (4.0%) LPS administration, but the amount of Rho123 excretion in bile decreased from 2.0 to 0.7% with LPS administration. Our findings suggested that hepatic P-glycoprotein expression and activity decreased on day 1 but recovered within 3 days, but there were no significant differences in the kidneys after LPS administration. These results suggested that the change in P-glycoprotein activity might be due to change in P-glycoprotein expression in the liver rather than the kidneys." @default.
- W2023766424 created "2016-06-24" @default.
- W2023766424 creator A5007422276 @default.
- W2023766424 creator A5017347957 @default.
- W2023766424 creator A5035160111 @default.
- W2023766424 creator A5039682115 @default.
- W2023766424 creator A5054782326 @default.
- W2023766424 creator A5058566482 @default.
- W2023766424 creator A5082589974 @default.
- W2023766424 creator A5088193800 @default.
- W2023766424 date "2010-06-01" @default.
- W2023766424 modified "2023-10-16" @default.
- W2023766424 title "Effects of lipopolysaccharide on P-glycoprotein expression and activity in the liver and kidneys" @default.
- W2023766424 cites W2009653237 @default.
- W2023766424 cites W2076392332 @default.
- W2023766424 cites W2077149526 @default.
- W2023766424 cites W2087571738 @default.
- W2023766424 cites W2097832070 @default.
- W2023766424 cites W2114816051 @default.
- W2023766424 cites W2123348451 @default.
- W2023766424 cites W2124344079 @default.
- W2023766424 cites W2151663689 @default.
- W2023766424 cites W2160486989 @default.
- W2023766424 cites W2160553550 @default.
- W2023766424 cites W97686115 @default.
- W2023766424 doi "https://doi.org/10.1016/j.ejphar.2010.03.024" @default.
- W2023766424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20353768" @default.
- W2023766424 hasPublicationYear "2010" @default.
- W2023766424 type Work @default.
- W2023766424 sameAs 2023766424 @default.
- W2023766424 citedByCount "8" @default.
- W2023766424 countsByYear W20237664242015 @default.
- W2023766424 countsByYear W20237664242021 @default.
- W2023766424 countsByYear W20237664242022 @default.
- W2023766424 countsByYear W20237664242023 @default.
- W2023766424 crossrefType "journal-article" @default.
- W2023766424 hasAuthorship W2023766424A5007422276 @default.
- W2023766424 hasAuthorship W2023766424A5017347957 @default.
- W2023766424 hasAuthorship W2023766424A5035160111 @default.
- W2023766424 hasAuthorship W2023766424A5039682115 @default.
- W2023766424 hasAuthorship W2023766424A5054782326 @default.
- W2023766424 hasAuthorship W2023766424A5058566482 @default.
- W2023766424 hasAuthorship W2023766424A5082589974 @default.
- W2023766424 hasAuthorship W2023766424A5088193800 @default.
- W2023766424 hasConcept C10146269 @default.
- W2023766424 hasConcept C108625454 @default.
- W2023766424 hasConcept C126322002 @default.
- W2023766424 hasConcept C133936738 @default.
- W2023766424 hasConcept C134018914 @default.
- W2023766424 hasConcept C153911025 @default.
- W2023766424 hasConcept C2778384902 @default.
- W2023766424 hasConcept C2778707650 @default.
- W2023766424 hasConcept C2778754761 @default.
- W2023766424 hasConcept C501593827 @default.
- W2023766424 hasConcept C55493867 @default.
- W2023766424 hasConcept C71924100 @default.
- W2023766424 hasConcept C86803240 @default.
- W2023766424 hasConceptScore W2023766424C10146269 @default.
- W2023766424 hasConceptScore W2023766424C108625454 @default.
- W2023766424 hasConceptScore W2023766424C126322002 @default.
- W2023766424 hasConceptScore W2023766424C133936738 @default.
- W2023766424 hasConceptScore W2023766424C134018914 @default.
- W2023766424 hasConceptScore W2023766424C153911025 @default.
- W2023766424 hasConceptScore W2023766424C2778384902 @default.
- W2023766424 hasConceptScore W2023766424C2778707650 @default.
- W2023766424 hasConceptScore W2023766424C2778754761 @default.
- W2023766424 hasConceptScore W2023766424C501593827 @default.
- W2023766424 hasConceptScore W2023766424C55493867 @default.
- W2023766424 hasConceptScore W2023766424C71924100 @default.
- W2023766424 hasConceptScore W2023766424C86803240 @default.
- W2023766424 hasIssue "1-3" @default.
- W2023766424 hasLocation W20237664241 @default.
- W2023766424 hasLocation W20237664242 @default.
- W2023766424 hasOpenAccess W2023766424 @default.
- W2023766424 hasPrimaryLocation W20237664241 @default.
- W2023766424 hasRelatedWork W2021846613 @default.
- W2023766424 hasRelatedWork W2022389305 @default.
- W2023766424 hasRelatedWork W2028993205 @default.
- W2023766424 hasRelatedWork W2059373368 @default.
- W2023766424 hasRelatedWork W2074872267 @default.
- W2023766424 hasRelatedWork W2088386184 @default.
- W2023766424 hasRelatedWork W2093166709 @default.
- W2023766424 hasRelatedWork W2104218156 @default.
- W2023766424 hasRelatedWork W2112174287 @default.
- W2023766424 hasRelatedWork W84213784 @default.
- W2023766424 hasVolume "636" @default.
- W2023766424 isParatext "false" @default.
- W2023766424 isRetracted "false" @default.
- W2023766424 magId "2023766424" @default.
- W2023766424 workType "article" @default.