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- W2023768026 abstract "Baseline and nicotine-modulated behaviors were assessed in mice harboring a null mutant allele of the nicotinic acetylcholine receptor (nAChR) subunit gene α2 (Chrna2). Homozygous Chrna2(-/-) mice are viable, show expected sex and Mendelian genotype ratios, and exhibit no gross neuroanatomical abnormalities. A broad range of behavioral tests designed to assess genotype-dependent effects on anxiety (elevated plus maze and light/dark box), motor coordination (narrow bean traverse and gait), and locomotor activity revealed no significant differences between mutant mice and age-matched wild-type littermates. Furthermore, a panel of tests measuring traits, such as body position, spontaneous activity, respiration, tremors, body tone, and startle response, revealed normal responses for Chrna2-null mutant mice. However, Chrna2(-/-) mice do exhibit a mild motor or coordination phenotype (a decreased latency to fall during the accelerating rotarod test) and possess an increased sensitivity to nicotine-induced analgesia in the hotplate assay. Relative to wild-type, Chrna2(-/-) mice show potentiated nicotine self-administration and withdrawal behaviors and exhibit a sex-dependent enhancement of nicotine-facilitated cued, but not trace or contextual, fear conditioning. Overall, our results suggest that loss of the mouse nAChR α2 subunit has very limited effects on baseline behavior but does lead to the potentiation of several nicotine-modulated behaviors." @default.
- W2023768026 created "2016-06-24" @default.
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- W2023768026 date "2013-05-01" @default.
- W2023768026 modified "2023-10-16" @default.
- W2023768026 title "Targeted Deletion of the Mouse 2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors" @default.
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- W2023768026 cites W1556927462 @default.
- W2023768026 cites W1570619508 @default.
- W2023768026 cites W1630155501 @default.
- W2023768026 cites W1847254590 @default.
- W2023768026 cites W1965573444 @default.
- W2023768026 cites W1966385194 @default.
- W2023768026 cites W1966873817 @default.
- W2023768026 cites W1974129689 @default.
- W2023768026 cites W1977511374 @default.
- W2023768026 cites W1977583617 @default.
- W2023768026 cites W1981720975 @default.
- W2023768026 cites W1983966279 @default.
- W2023768026 cites W1985650014 @default.
- W2023768026 cites W1986388523 @default.
- W2023768026 cites W1986445622 @default.
- W2023768026 cites W1988099473 @default.
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- W2023768026 cites W2001829289 @default.
- W2023768026 cites W2007578371 @default.
- W2023768026 cites W2013666305 @default.
- W2023768026 cites W2014311492 @default.
- W2023768026 cites W2016630466 @default.
- W2023768026 cites W2020567468 @default.
- W2023768026 cites W2024903765 @default.
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- W2023768026 cites W2040033421 @default.
- W2023768026 cites W2047331648 @default.
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- W2023768026 cites W2064507133 @default.
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- W2023768026 cites W2112994833 @default.
- W2023768026 cites W2129666689 @default.
- W2023768026 cites W2131859094 @default.
- W2023768026 cites W2132764009 @default.
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- W2023768026 doi "https://doi.org/10.1523/jneurosci.4731-12.2013" @default.
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