FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023772405> ?p ?o ?g. }

• W2023772405 endingPage "527" @default.
• W2023772405 startingPage "521" @default.
• W2023772405 abstract "N-aspartylchlorin e6 (talaporfin) concentrations in cancer cells, mouse liver tissues, and human plasma specimens were determined with fluorescence microtiter plate analysis. Talaporfin standard curves were obtained in each of the sample specimens of cells, mouse tissues, or human plasma including serial concentration of talaporfin. The correlation co-efficiencies (r2) of talaporfin standard curves were 0.99-1.00, and the CV less than 5%. Talaporfin incorporation into cells of human breast cancer cell line MCF-7 after incubating with 25 μg/mL talaporfin for up to 24 h revealed that the t-max of the drug incorporation was approximately 5 h, and the maximum drug concentration incorporated was 25 μg/107 cells. Talaporfin incorporation into MCF-7 cells was significantly decreased in the presence of 3 μg/mL cyc-losporine (p < 0.05). Balb/c nu/nu mice implanted human cholangiocarcinoma NOZ cells in liver were administered intravenously 5mg/mouse of talaporfin, and the tissues of normal liver and tumor, as well as plasma specimens, were analyzed for talaporfin concentrations. The mean (SD) of talaporfin concentration in plasma after 30 min of administration was 41.6 (2.3) μg/mL, while the level decreased to undetectable concentrations 2 h after administration. In contrast, the talaporfin concentrations in normal and tumor tissues after 30 min of administration were 1.1-7.8 μg/g tissue, and the level slightly increased or was almost maintained for up to 2-4 h after administration. The heparinized blood of the healthy subjects was incubated with 25 μg/mL talaporfin for up to 24 h. The plasma talaporfin concentration did not significantly change during the incubation, and thus talaporfin appears not to be incorporated into the blood cells. We established rapid and simple analysis procedures of talaporfin in biological specimens using a fluorescence microtiter plate assay. Using this assay procedure, the unique pattern of talaporfin disposition and pharmacokinetics were revealed in human cancer cells, liver tissues of tumor bearing mice, and human blood." @default.
• W2023772405 created "2016-06-24" @default.
• W2023772405 creator A5017611425 @default.
• W2023772405 creator A5034961223 @default.
• W2023772405 creator A5037091135 @default.
• W2023772405 creator A5040543323 @default.
• W2023772405 creator A5051628443 @default.
• W2023772405 creator A5053765147 @default.
• W2023772405 creator A5063758486 @default.
• W2023772405 creator A5068746491 @default.
• W2023772405 creator A5074674530 @default.
• W2023772405 creator A5078934346 @default.
• W2023772405 creator A5091036671 @default.
• W2023772405 date "2012-01-01" @default.
• W2023772405 modified "2023-10-02" @default.
• W2023772405 title "Rapid and Simple Analysis of <i>N</i>-Aspartylchlor in E6 (Talaporfin) Using Fluorescence Microtiterplate and Its Application for Determination in Cells, Tissues and Blood" @default.
• W2023772405 cites W2006584068 @default.
• W2023772405 cites W2013067955 @default.
• W2023772405 cites W2028736046 @default.
• W2023772405 cites W2032626826 @default.
• W2023772405 cites W2041480184 @default.
• W2023772405 cites W2041941116 @default.
• W2023772405 cites W2068821001 @default.
• W2023772405 cites W2072337982 @default.
• W2023772405 cites W2089227323 @default.
• W2023772405 cites W2089488649 @default.
• W2023772405 cites W2095399145 @default.
• W2023772405 cites W2104225189 @default.
• W2023772405 cites W2152057262 @default.
• W2023772405 cites W2165822660 @default.
• W2023772405 cites W2170324281 @default.
• W2023772405 cites W246344969 @default.
• W2023772405 cites W3133924569 @default.
• W2023772405 doi "https://doi.org/10.4236/jct.2012.35067" @default.
• W2023772405 hasPublicationYear "2012" @default.
• W2023772405 type Work @default.
• W2023772405 sameAs 2023772405 @default.
• W2023772405 citedByCount "2" @default.
• W2023772405 countsByYear W20237724052015 @default.
• W2023772405 countsByYear W20237724052019 @default.
• W2023772405 crossrefType "journal-article" @default.
• W2023772405 hasAuthorship W2023772405A5017611425 @default.
• W2023772405 hasAuthorship W2023772405A5034961223 @default.
• W2023772405 hasAuthorship W2023772405A5037091135 @default.
• W2023772405 hasAuthorship W2023772405A5040543323 @default.
• W2023772405 hasAuthorship W2023772405A5051628443 @default.
• W2023772405 hasAuthorship W2023772405A5053765147 @default.
• W2023772405 hasAuthorship W2023772405A5063758486 @default.
• W2023772405 hasAuthorship W2023772405A5068746491 @default.
• W2023772405 hasAuthorship W2023772405A5074674530 @default.
• W2023772405 hasAuthorship W2023772405A5078934346 @default.
• W2023772405 hasAuthorship W2023772405A5091036671 @default.
• W2023772405 hasBestOaLocation W20237724051 @default.
• W2023772405 hasConcept C153911025 @default.
• W2023772405 hasConcept C16685009 @default.
• W2023772405 hasConcept C185592680 @default.
• W2023772405 hasConcept C190283241 @default.
• W2023772405 hasConcept C55493867 @default.
• W2023772405 hasConcept C71924100 @default.
• W2023772405 hasConcept C86803240 @default.
• W2023772405 hasConceptScore W2023772405C153911025 @default.
• W2023772405 hasConceptScore W2023772405C16685009 @default.
• W2023772405 hasConceptScore W2023772405C185592680 @default.
• W2023772405 hasConceptScore W2023772405C190283241 @default.
• W2023772405 hasConceptScore W2023772405C55493867 @default.
• W2023772405 hasConceptScore W2023772405C71924100 @default.
• W2023772405 hasConceptScore W2023772405C86803240 @default.
• W2023772405 hasIssue "05" @default.
• W2023772405 hasLocation W20237724051 @default.
• W2023772405 hasOpenAccess W2023772405 @default.
• W2023772405 hasPrimaryLocation W20237724051 @default.
• W2023772405 hasRelatedWork W2352517883 @default.
• W2023772405 hasRelatedWork W2355678225 @default.
• W2023772405 hasRelatedWork W2358987834 @default.
• W2023772405 hasRelatedWork W2363034077 @default.
• W2023772405 hasRelatedWork W2367454707 @default.
• W2023772405 hasRelatedWork W2373412498 @default.
• W2023772405 hasRelatedWork W2379861500 @default.
• W2023772405 hasRelatedWork W2432135151 @default.
• W2023772405 hasRelatedWork W2465403515 @default.
• W2023772405 hasRelatedWork W2472820331 @default.
• W2023772405 hasVolume "03" @default.
• W2023772405 isParatext "false" @default.
• W2023772405 isRetracted "false" @default.
• W2023772405 magId "2023772405" @default.
• W2023772405 workType "article" @default.