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- W2023773946 abstract "Acyclovir (ACV) is almost entirely eliminated by the kidneys and has a terminal plasma half-life (t½) of 2 to 3 hr in subjects with normal renal function. To determine the drug's kinetics and tolerance in patients with severe renal failure, six anuric subjects on long-term hemodialysis were studied. Each received a 1-hr infusion of 2.5 mg/kg IV ACV. The kinetics are well described by a two-compartment open model. ACV terminal plasma t½ and the total body clearance were 19.5 ± 5.9 hr (x̄ ± SD) and 28.6 ± 9.5 ml / min / 1.73 m2. Peak (end of infusion) and 8- and 24-hr plasma ACV concentrations were 37.5 ± 23.3, 10.3 ± 2.9, and 6.4 ±2.4 μM. Approximately 48 hr after the start of the infusion the subjects were hemodialyzed for 6 hr. The pre- and posthemodialysis ACV plasma levels were 2.74 ± 1.38 and 1.11 ± 0.60 μM. The terminal ACV t½ during hemodialysis was 5.7 ± 0.85 hr. During hemodialysis paired arterial and venous samples showed that ACV was readily dialyzed, with a mean coefficient of extraction of 0.45 ± 0.12. The dialysis clearance of acyclovir was 81.8 ± 12.6 ml / min. None of the patients had any ACV-related adverse effects. Since ACV elimination is markly reduced in end-stage renal failure and because ACV is readily hemodialyzible, dosage modifications are needed to avoid cumulation and to replace dialyzed drug. Clinical Pharmacology and Therapeutics (1982) 31, 594–601; doi:10.1038/clpt.1982.83" @default.
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- W2023773946 date "1982-05-01" @default.
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- W2023773946 title "Acyclovir kinetics in end-stage renal disease" @default.
- W2023773946 doi "https://doi.org/10.1038/clpt.1982.83" @default.
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