Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023774523> ?p ?o ?g. }
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- W2023774523 startingPage "6152" @default.
- W2023774523 abstract "Weakly electric fish can enhance the detection and localization of important signals such as those of prey in part by cancellation of redundant spatially diffuse electric signals due to, e.g., their tail bending. The cancellation mechanism is based on descending input, conveyed by parallel fibers emanating from cerebellar granule cells, that produces a negative image of the global low-frequency signals in pyramidal cells within the first-order electrosensory region, the electrosensory lateral line lobe (ELL). Here we demonstrate that the parallel fiber synaptic input to ELL pyramidal cell undergoes long-term depression (LTD) whenever both parallel fiber afferents and their target cells are stimulated to produce paired burst discharges. Paired large bursts (4-4) induce robust LTD over pre-post delays of up to +/-50 ms, whereas smaller bursts (2-2) induce weaker LTD. Single spikes (either presynaptic or postsynaptic) paired with bursts did not induce LTD. Tetanic presynaptic stimulation was also ineffective in inducing LTD. Thus, we have demonstrated a form of anti-Hebbian LTD that depends on the temporal correlation of burst discharge. We then demonstrated that the burst-induced LTD is postsynaptic and requires the NR2B subunit of the NMDA receptor, elevation of postsynaptic Ca(2+), and activation of CaMKIIbeta. A model incorporating local inhibitory circuitry and previously identified short-term presynaptic potentiation of the parallel fiber synapses further suggests that the combination of burst-induced LTD, presynaptic potentiation, and local inhibition may be sufficient to explain the generation of the negative image and cancellation of redundant sensory input by ELL pyramidal cells." @default.
- W2023774523 created "2016-06-24" @default.
- W2023774523 creator A5019782421 @default.
- W2023774523 creator A5029550387 @default.
- W2023774523 creator A5064386682 @default.
- W2023774523 date "2010-04-28" @default.
- W2023774523 modified "2023-10-18" @default.
- W2023774523 title "Burst-Induced Anti-Hebbian Depression Acts through Short-Term Synaptic Dynamics to Cancel Redundant Sensory Signals" @default.
- W2023774523 cites W1500250295 @default.
- W2023774523 cites W1538637720 @default.
- W2023774523 cites W1540069135 @default.
- W2023774523 cites W1564731592 @default.
- W2023774523 cites W1573265402 @default.
- W2023774523 cites W1587725414 @default.
- W2023774523 cites W1636577383 @default.
- W2023774523 cites W163811128 @default.
- W2023774523 cites W1869243795 @default.
- W2023774523 cites W1878366586 @default.
- W2023774523 cites W1972270334 @default.
- W2023774523 cites W1973436856 @default.
- W2023774523 cites W1975275982 @default.
- W2023774523 cites W1975412204 @default.
- W2023774523 cites W1976435105 @default.
- W2023774523 cites W1981156067 @default.
- W2023774523 cites W1986291163 @default.
- W2023774523 cites W1987173409 @default.
- W2023774523 cites W1987832351 @default.
- W2023774523 cites W1990127768 @default.
- W2023774523 cites W1994320695 @default.
- W2023774523 cites W1997956229 @default.
- W2023774523 cites W2003636595 @default.
- W2023774523 cites W2007195897 @default.
- W2023774523 cites W2007393704 @default.
- W2023774523 cites W2009769713 @default.
- W2023774523 cites W2011845415 @default.
- W2023774523 cites W2016300780 @default.
- W2023774523 cites W2017563273 @default.
- W2023774523 cites W2019432346 @default.
- W2023774523 cites W2020038037 @default.
- W2023774523 cites W2021235911 @default.
- W2023774523 cites W2025542749 @default.
- W2023774523 cites W2027565428 @default.
- W2023774523 cites W2028594041 @default.
- W2023774523 cites W2030924592 @default.
- W2023774523 cites W2032596004 @default.
- W2023774523 cites W2039993349 @default.
- W2023774523 cites W2042768551 @default.
- W2023774523 cites W2044508449 @default.
- W2023774523 cites W2046899508 @default.
- W2023774523 cites W2047505499 @default.
- W2023774523 cites W2049511526 @default.
- W2023774523 cites W2050981084 @default.
- W2023774523 cites W2060200435 @default.
- W2023774523 cites W2060580046 @default.
- W2023774523 cites W2061652205 @default.
- W2023774523 cites W2065158671 @default.
- W2023774523 cites W2066507418 @default.
- W2023774523 cites W2075075476 @default.
- W2023774523 cites W2078594622 @default.
- W2023774523 cites W2079302576 @default.
- W2023774523 cites W2080213202 @default.
- W2023774523 cites W2080278491 @default.
- W2023774523 cites W2082904387 @default.
- W2023774523 cites W2086156968 @default.
- W2023774523 cites W2088847276 @default.
- W2023774523 cites W2093219120 @default.
- W2023774523 cites W2094549318 @default.
- W2023774523 cites W2096473662 @default.
- W2023774523 cites W2099252376 @default.
- W2023774523 cites W2101218723 @default.
- W2023774523 cites W2102268999 @default.
- W2023774523 cites W2103225200 @default.
- W2023774523 cites W2107433900 @default.
- W2023774523 cites W2110456678 @default.
- W2023774523 cites W2110521805 @default.
- W2023774523 cites W2110591684 @default.
- W2023774523 cites W2111893421 @default.
- W2023774523 cites W2112666468 @default.
- W2023774523 cites W2118354429 @default.
- W2023774523 cites W2120805776 @default.
- W2023774523 cites W2130832907 @default.
- W2023774523 cites W2130851537 @default.
- W2023774523 cites W2135358145 @default.
- W2023774523 cites W2140999596 @default.
- W2023774523 cites W2148429387 @default.
- W2023774523 cites W2148773920 @default.
- W2023774523 cites W2149250354 @default.
- W2023774523 cites W2151029243 @default.
- W2023774523 cites W2151542182 @default.
- W2023774523 cites W2152419163 @default.
- W2023774523 cites W2154045630 @default.
- W2023774523 cites W2158814307 @default.
- W2023774523 cites W2159160021 @default.
- W2023774523 cites W2161152720 @default.
- W2023774523 cites W2161998020 @default.
- W2023774523 cites W2166889327 @default.
- W2023774523 cites W2170177112 @default.
- W2023774523 cites W2170591768 @default.