Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023774745> ?p ?o ?g. }
- W2023774745 abstract "Centrosome duplication is licensed by the disengagement, or ‘uncoupling’, of centrioles during late mitosis. However, arrest of cells in G2 can trigger premature centriole disengagement. Here, we show that premature disengagement results from untimely activation of the APC/C leading to securin degradation and release of active separase. APC/C activation during G2 arrest is dependent on Plk1-mediated degradation of the APC/C inhibitor, Emi1, but Plk1 also has a second APC/C-independent role in promoting disengagement. Importantly, APC/C and Plk1 activity also stimulate centriole disengagement in response to hydroxyurea or DNA damage-induced cell cycle arrest and this leads to centrosome amplification. However, the re-duplication of disengaged centrioles is dependent on Cdk2 activity and Cdk2 activation coincides with a subsequent inactivation of the APC/C and re-accumulation of cyclin A. Release from these arrests leads to mitotic entry but, due to the presence of disengaged and/or amplified centrosomes, formation of abnormal mitotic spindles that lead to chromosome missegregation. Thus, oscillation of APC/C activity during cell cycle arrest promotes both centrosome amplification and genome instability." @default.
- W2023774745 created "2016-06-24" @default.
- W2023774745 creator A5005427330 @default.
- W2023774745 creator A5025469280 @default.
- W2023774745 creator A5041325599 @default.
- W2023774745 creator A5066607841 @default.
- W2023774745 creator A5088173320 @default.
- W2023774745 date "2012-01-01" @default.
- W2023774745 modified "2023-10-16" @default.
- W2023774745 title "Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification" @default.
- W2023774745 cites W131532494 @default.
- W2023774745 cites W1502721583 @default.
- W2023774745 cites W1537737236 @default.
- W2023774745 cites W1565504254 @default.
- W2023774745 cites W1963937857 @default.
- W2023774745 cites W1963951796 @default.
- W2023774745 cites W1963981052 @default.
- W2023774745 cites W1964496691 @default.
- W2023774745 cites W1965239527 @default.
- W2023774745 cites W1970741091 @default.
- W2023774745 cites W1976311440 @default.
- W2023774745 cites W1977721021 @default.
- W2023774745 cites W1978143866 @default.
- W2023774745 cites W1982090173 @default.
- W2023774745 cites W1986535777 @default.
- W2023774745 cites W1992425431 @default.
- W2023774745 cites W1995078993 @default.
- W2023774745 cites W1997408971 @default.
- W2023774745 cites W2002083668 @default.
- W2023774745 cites W2004548769 @default.
- W2023774745 cites W2005073257 @default.
- W2023774745 cites W2007546535 @default.
- W2023774745 cites W2008751957 @default.
- W2023774745 cites W2011207690 @default.
- W2023774745 cites W2013031766 @default.
- W2023774745 cites W2013548561 @default.
- W2023774745 cites W2014936015 @default.
- W2023774745 cites W2018239751 @default.
- W2023774745 cites W2019013949 @default.
- W2023774745 cites W2022696578 @default.
- W2023774745 cites W2025760415 @default.
- W2023774745 cites W2027520391 @default.
- W2023774745 cites W2028791725 @default.
- W2023774745 cites W2029620430 @default.
- W2023774745 cites W2030242816 @default.
- W2023774745 cites W2031372750 @default.
- W2023774745 cites W2038747158 @default.
- W2023774745 cites W2040727271 @default.
- W2023774745 cites W2042039168 @default.
- W2023774745 cites W2042146481 @default.
- W2023774745 cites W2044367190 @default.
- W2023774745 cites W2044975729 @default.
- W2023774745 cites W2046347502 @default.
- W2023774745 cites W2046691565 @default.
- W2023774745 cites W2049460100 @default.
- W2023774745 cites W2054146568 @default.
- W2023774745 cites W2058537133 @default.
- W2023774745 cites W2059706603 @default.
- W2023774745 cites W2060387325 @default.
- W2023774745 cites W2065629914 @default.
- W2023774745 cites W2068718775 @default.
- W2023774745 cites W2070484339 @default.
- W2023774745 cites W2072895299 @default.
- W2023774745 cites W2073031672 @default.
- W2023774745 cites W2074113529 @default.
- W2023774745 cites W2076670220 @default.
- W2023774745 cites W2083468899 @default.
- W2023774745 cites W2089685532 @default.
- W2023774745 cites W2100069305 @default.
- W2023774745 cites W2100300898 @default.
- W2023774745 cites W2103166084 @default.
- W2023774745 cites W2110337318 @default.
- W2023774745 cites W2111054613 @default.
- W2023774745 cites W2111837850 @default.
- W2023774745 cites W2115206894 @default.
- W2023774745 cites W2117695829 @default.
- W2023774745 cites W2120785595 @default.
- W2023774745 cites W2126344344 @default.
- W2023774745 cites W2126531920 @default.
- W2023774745 cites W2128126810 @default.
- W2023774745 cites W2128508997 @default.
- W2023774745 cites W2134590240 @default.
- W2023774745 cites W2142451800 @default.
- W2023774745 cites W2143720287 @default.
- W2023774745 cites W2143927826 @default.
- W2023774745 cites W2144778448 @default.
- W2023774745 cites W2144975263 @default.
- W2023774745 cites W2145930496 @default.
- W2023774745 cites W2146135835 @default.
- W2023774745 cites W2146703382 @default.
- W2023774745 cites W2151602082 @default.
- W2023774745 cites W2151784069 @default.
- W2023774745 cites W2152728124 @default.
- W2023774745 cites W2157374362 @default.
- W2023774745 cites W2159243681 @default.
- W2023774745 cites W2164303054 @default.
- W2023774745 cites W2165703806 @default.
- W2023774745 cites W2166053174 @default.
- W2023774745 cites W2166080650 @default.
- W2023774745 cites W2167732550 @default.