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• W2023774806 abstract "The receptor for transferrin plays an important role both in tumor cell growth and in hemoglobin synthesis. In this paper, we demonstrate that the monoclonal antibody 426 to human transferrin receptor inhibits iron uptake in the human leukemic K562 cell line and suppresses hemoglobin accumulation in K562 cells induced to erythroid differentiation by butyric acid. In contrast, only slight inhibitory effects were observed on cell proliferation of both uninduced and erythroid-induced K562 cells treated with the 426 monoclonal antibody. In addition, the 426 monoclonal antibody to human transferrin receptor does not inhibit butyric acid-induced accumulation of γ-globin mRNA. The effect of the 426 monoclonal antibody on hemoglobin synthesis appears to be restricted to human cell lines, as murine Friend erythroleukemic cells undergo erythroid differentiation when cultured in the presence of hexamethylenebisacetamide plus the 426 monoclonal antibody. The findings reported in this paper suggest (a) a dissociation of iron transport and accumulation of heme molecules from the expression of globin genes and (b) a different requirement of iron uptake by different iron-dependent functions such as cell proliferation and hemoglobin expression." @default.
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• W2023774806 date "1986-04-01" @default.
• W2023774806 modified "2023-09-26" @default.
• W2023774806 title "Human leukemic K562 cells: Suppression of hemoglobin accumulation by a monoclonal antibody to human transferrin receptor" @default.
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• W2023774806 doi "https://doi.org/10.1016/0167-4889(86)90138-2" @default.
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