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- W2023775274 abstract "Abstract Due to increasing use of diesel-powered vehicles, it has become necessary to assess adverse biological effects of diesel emissions in our environment. The present data describe the effects of inhalation exposure of diesel emission on the specific activities of aryl hydrocarbon hydroxylase (AHH) and epoxide hydrase (EH) in rat lung, liver, testis, and prostate gland. Adult CD strain, Sprague-Dawley male rats (8–10 weeks old) were exposed to diesel emission (1:13 dilution) containing 14.2 ppm ( v v ) total hydrocarbon, 20 hr/day for 42 days. Although liver exhibited the greatest overall AHH activity among the organs tested, the percentage increase over control values was highest in the prostate gland. On Day 15 of exposure, AHH activity had increased to 4.5-fold that of the control and remained elevated throughout the entire exposure period. In contrast, AHH induction in liver and lung occurred on Day 33 of exposure, and the maximum AHH induction was observed on Day 42 (1.4- and 1.3-fold increase in lung and liver, respectively). In all the organs tested, EH activity was not changed significantly during the experimental period." @default.
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- W2023775274 date "1980-01-01" @default.
- W2023775274 modified "2023-09-27" @default.
- W2023775274 title "Aryl hydrocarbon hydroxylase induction in rat lung, liver, and male reproductive organs following inhalation exposure to diesel emission" @default.
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- W2023775274 doi "https://doi.org/10.1016/0041-008x(80)90258-6" @default.
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