Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023776685> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2023776685 endingPage "702" @default.
- W2023776685 startingPage "699" @default.
- W2023776685 abstract "Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas (I-X: X = -OCH3, -CH3, -H, -Cl, and -COCH3) and of their corresponding phenyl isocyanates (II-X: X = -OCH3, -CH3, -H, -Cl and -COCH3) to the amino group of 5'-amino-5'-deoxythymidine have been kinetically studied in a PBS. The pseudo-first-order rate constants (kc x 10(4) s-1, 37 degrees C) are 9.21 for I-OCH3, 5.11 for I-CH3, 20.1 for I-H, 3.45 for I-Cl and 5.75 for I-COCH3. These rate constants correlated well with the tumorigenic potency of I-X to mouse skin (r = 0.761), but did not correlate with the other factors [solvolytic reactivity, alkylating activity to 4-(p-nitrobenzyl)pyridine, and mutagenicity on Salmonella typhimurium TA1535]. When the rate ratio (kc/ks) of the carbamoylation (kc) with the solvolysis (ks) was compared with the tumorigenic potency, a much better correlation was found between them (r = 0.876). Since II-X were too reactive to measure their kinetic data, the extent of their reactions at the 60 min time point was compared with the reactions of I-X. The reactivity of II-X (II-OCH3 greater than II-CH3 greater than II-H greater than II-Cl greater than II-COCH3) did not correlate with that of I-X (I-H greater than I-OCH3 greater than I-CH3 greater than I-Cl greater than I-COCH3), but both I-X and II-X gave the same carbamoylated and solvolysis products. The present results suggest that carbamoylation of amino groups in cellular constituents by N-nitrosoureas is a critical factor in inducing mouse skin tumors by the agents and that the generated isocyanates may not be the key intermediates for the carbamoylation reactions." @default.
- W2023776685 created "2016-06-24" @default.
- W2023776685 creator A5052351040 @default.
- W2023776685 date "1992-01-01" @default.
- W2023776685 modified "2023-09-23" @default.
- W2023776685 title "Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas and corresponding phenyl isocyanates to 5'-amino-5'-deoxythymidine: importance of carbamoylation in mouse skin carcinogenic processes" @default.
- W2023776685 doi "https://doi.org/10.1093/carcin/13.4.699" @default.
- W2023776685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1576720" @default.
- W2023776685 hasPublicationYear "1992" @default.
- W2023776685 type Work @default.
- W2023776685 sameAs 2023776685 @default.
- W2023776685 citedByCount "2" @default.
- W2023776685 crossrefType "journal-article" @default.
- W2023776685 hasAuthorship W2023776685A5052351040 @default.
- W2023776685 hasConcept C114246631 @default.
- W2023776685 hasConcept C121332964 @default.
- W2023776685 hasConcept C142724271 @default.
- W2023776685 hasConcept C148898269 @default.
- W2023776685 hasConcept C155647269 @default.
- W2023776685 hasConcept C178790620 @default.
- W2023776685 hasConcept C185592680 @default.
- W2023776685 hasConcept C202751555 @default.
- W2023776685 hasConcept C204787440 @default.
- W2023776685 hasConcept C2776910235 @default.
- W2023776685 hasConcept C2779293432 @default.
- W2023776685 hasConcept C2779485729 @default.
- W2023776685 hasConcept C2780263894 @default.
- W2023776685 hasConcept C2781076698 @default.
- W2023776685 hasConcept C55493867 @default.
- W2023776685 hasConcept C57992300 @default.
- W2023776685 hasConcept C62520636 @default.
- W2023776685 hasConcept C71240020 @default.
- W2023776685 hasConcept C71924100 @default.
- W2023776685 hasConcept C93391505 @default.
- W2023776685 hasConcept C94412978 @default.
- W2023776685 hasConceptScore W2023776685C114246631 @default.
- W2023776685 hasConceptScore W2023776685C121332964 @default.
- W2023776685 hasConceptScore W2023776685C142724271 @default.
- W2023776685 hasConceptScore W2023776685C148898269 @default.
- W2023776685 hasConceptScore W2023776685C155647269 @default.
- W2023776685 hasConceptScore W2023776685C178790620 @default.
- W2023776685 hasConceptScore W2023776685C185592680 @default.
- W2023776685 hasConceptScore W2023776685C202751555 @default.
- W2023776685 hasConceptScore W2023776685C204787440 @default.
- W2023776685 hasConceptScore W2023776685C2776910235 @default.
- W2023776685 hasConceptScore W2023776685C2779293432 @default.
- W2023776685 hasConceptScore W2023776685C2779485729 @default.
- W2023776685 hasConceptScore W2023776685C2780263894 @default.
- W2023776685 hasConceptScore W2023776685C2781076698 @default.
- W2023776685 hasConceptScore W2023776685C55493867 @default.
- W2023776685 hasConceptScore W2023776685C57992300 @default.
- W2023776685 hasConceptScore W2023776685C62520636 @default.
- W2023776685 hasConceptScore W2023776685C71240020 @default.
- W2023776685 hasConceptScore W2023776685C71924100 @default.
- W2023776685 hasConceptScore W2023776685C93391505 @default.
- W2023776685 hasConceptScore W2023776685C94412978 @default.
- W2023776685 hasIssue "4" @default.
- W2023776685 hasLocation W20237766851 @default.
- W2023776685 hasLocation W20237766852 @default.
- W2023776685 hasOpenAccess W2023776685 @default.
- W2023776685 hasPrimaryLocation W20237766851 @default.
- W2023776685 hasRelatedWork W2024925552 @default.
- W2023776685 hasRelatedWork W2046749010 @default.
- W2023776685 hasRelatedWork W2078235500 @default.
- W2023776685 hasRelatedWork W2079423207 @default.
- W2023776685 hasRelatedWork W2088431388 @default.
- W2023776685 hasRelatedWork W2094190383 @default.
- W2023776685 hasRelatedWork W2324898221 @default.
- W2023776685 hasRelatedWork W2355029734 @default.
- W2023776685 hasRelatedWork W2950471824 @default.
- W2023776685 hasRelatedWork W4240138400 @default.
- W2023776685 hasVolume "13" @default.
- W2023776685 isParatext "false" @default.
- W2023776685 isRetracted "false" @default.
- W2023776685 magId "2023776685" @default.
- W2023776685 workType "article" @default.