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- W2023776847 abstract "1 The therapeutic efficacy of combined treatment of sodium nitrite (NaNO 2 ) and 4-dimethylaminophenol (DMAP) or hydroxylamine (H 2 NOH) was investigated in potassium cyanide (KCN) intoxication in male rats. 2 Therapy with NaNO 2 (0.27 mmol kg -1 ) + DMAP (0.09 mmol kg -1 ) or NaNO 2 + H 2 NOH (0.09 mmol kg -1 , produced a protection index (ratio of LD 50 of KCN in rats receiving therapy to an LD 50 of KCN in rats given only 0.9% saline) of 2.5 and 2.0 respectively. 3 Both the regimens exhibited a beneficial effect in terms of improving the survival time and postural defects in rats exposed to 2 LD 50 KCN. 4 NaNO 2 + DMAP showed a significant protective effect in the disposition of the plasma cyanide level at different time intervals. 5 The NaNO 2 + DMAP regimen was superior to NaNO 2 + H 2 NOH in terms of reactivating the inhibited brain cytochrome oxidase enzyme. 6 The addition of sodium thiosulphate (Na 2 S 2 O 3 ) in both the regimens increased the degree of protection. 7 The results suggest that combined therapy with NaNO 2 + DMAP could significantly reduce the toxic effects of cyanide, compared with NaNO 2 +H 2 NOH treatment." @default.
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- W2023776847 title "Therapeutic efficacy of sodium nitrite and 4-dimethylaminophenol or hydroxylamine co-administration against cyanide poisoning in rats" @default.
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- W2023776847 doi "https://doi.org/10.1177/096032719501400107" @default.
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