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- W2023777617 abstract "The pharmacokinetics and urinary excretion of a single dyphylline dose were studied in five normal volunteers. The mean dyphylline half-life was 1.8 ± 0.2 hr; the mean total body clearance rate and mean renal clearance rate were 333 ± 62 and 276 ± 52 ml/min, respectively; and the mean volume of distribution was 0.8 ± 0.2 liter/kg. In the urine, 83 ± 5% of the dose was excreted as unchanged drug, and theophylline was not detected. Dyphylline doses of 19-27 mg/kg, resulting in peak serum dyphylline concentrations of 19.3-23.5 μg/ml, were tolerated well by four subjects. One subject had a severe headache following a 128-mg/kg dose, associated with a peak serum dyphylline concentration of 36.4 μg/ml. This study confirms speculation that dyphylline is not metabolized to theophylline in vivo." @default.
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- W2023777617 date "1979-10-01" @default.
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- W2023777617 title "Urinary Excretion of Dyphylline in Humans" @default.
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- W2023777617 doi "https://doi.org/10.1002/jps.2600681038" @default.
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