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- W2023778146 abstract "Effects of nicotine administered systemically or locally on locomotor activity and l-3,4-dihydroxyphenylalanine (l-DOPA) release were studied using microdialysis in the nucleus accumbens of freely moving rats. The basal l-DOPA release was Ca2+-dependent and tetrodotoxin-sensitive. Systemic nicotine (1 mg/kg s.c.) increased locomotor activity and l-DOPA release preferentially in the nucleus accumbens as compared with the striatum. Injection of nicotine (30 μg) into the ventral tegmental area increased locomotor activity and l-DOPA release from the nucleus accumbens. These increases were antagonized by prior injection of mecamylamine into the ventral tegmental area. Nicotine induces locomotor activity and l-DOPA release from the nucleus accumbens via nicotinic receptors in the ventral tegmental area. The release may be relevant to behavioral actions of nicotine." @default.
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- W2023778146 date "1996-08-01" @default.
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- W2023778146 title "Ventral tegmental injection of nicotine induces locomotor activity and l-DOPA release from nucleus accumbens" @default.
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- W2023778146 doi "https://doi.org/10.1016/0014-2999(96)00458-x" @default.
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