Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023778963> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2023778963 endingPage "143" @default.
- W2023778963 startingPage "137" @default.
- W2023778963 abstract "Five compounds -1, 2, 3, 4, and 5 were placed into tissue culture similarly to isoniazid at concentrations ranging from 0.03125 mg/mL to 2.00 mg/mL, with Mycobacterium tuberculosis. Compounds 1 and 5 showed substantial growth inhibition at the lowest concentration of 0.03125 mg/mL, whereas compounds 2, 3, and 4 demonstrated similar effects starting at 0.0625 mg/mL. Compounds 2 and 3 showed polar surface area of 55.12 A2, suitable for penetrating the blood-brain barrier. Hierarchical cluster analysis, principal coordinates analysis, and principal components analysis were utilized to analyze numerical values of properties for all drugs and showed that isoniazid is highly similar to compounds 2 and 3, with compound 1 distinct from all other drugs, with compounds 4 and 5 having high similarity. This comparison was confirmed by by principal coordinates analysis and principal components analysis. Multiple regression analysis produced an equation that accurately predicts formula weight for similar drugs utilizing molar refractivity, molar volume, parachor, and polar surface area. Compounds 1, 2, 3, and isoniazid showed no violations of the Rule of 5, which indicates properties that enhance drug absorbance. Compounds 2, 3, 4, and 5 were synthesized by utilizing microwave methodology. Keywords: Tuberculosis, Mycobacteria, Hydrazine, Isoniazid, Antibacterial, MDR" @default.
- W2023778963 created "2016-06-24" @default.
- W2023778963 creator A5012875732 @default.
- W2023778963 creator A5026103904 @default.
- W2023778963 creator A5082816905 @default.
- W2023778963 date "2007-03-01" @default.
- W2023778963 modified "2023-09-27" @default.
- W2023778963 title "Design and In Vitro Evaluation of Five Inhibitors of Mycobacterium Tuberculosis" @default.
- W2023778963 doi "https://doi.org/10.2174/157018007779422451" @default.
- W2023778963 hasPublicationYear "2007" @default.
- W2023778963 type Work @default.
- W2023778963 sameAs 2023778963 @default.
- W2023778963 citedByCount "0" @default.
- W2023778963 crossrefType "journal-article" @default.
- W2023778963 hasAuthorship W2023778963A5012875732 @default.
- W2023778963 hasAuthorship W2023778963A5026103904 @default.
- W2023778963 hasAuthorship W2023778963A5082816905 @default.
- W2023778963 hasConcept C142724271 @default.
- W2023778963 hasConcept C154945302 @default.
- W2023778963 hasConcept C164126121 @default.
- W2023778963 hasConcept C185592680 @default.
- W2023778963 hasConcept C27438332 @default.
- W2023778963 hasConcept C2776597398 @default.
- W2023778963 hasConcept C2776967927 @default.
- W2023778963 hasConcept C2777975735 @default.
- W2023778963 hasConcept C2780374374 @default.
- W2023778963 hasConcept C2780708107 @default.
- W2023778963 hasConcept C2781069245 @default.
- W2023778963 hasConcept C41008148 @default.
- W2023778963 hasConcept C43617362 @default.
- W2023778963 hasConcept C71240020 @default.
- W2023778963 hasConcept C71924100 @default.
- W2023778963 hasConcept C98015330 @default.
- W2023778963 hasConceptScore W2023778963C142724271 @default.
- W2023778963 hasConceptScore W2023778963C154945302 @default.
- W2023778963 hasConceptScore W2023778963C164126121 @default.
- W2023778963 hasConceptScore W2023778963C185592680 @default.
- W2023778963 hasConceptScore W2023778963C27438332 @default.
- W2023778963 hasConceptScore W2023778963C2776597398 @default.
- W2023778963 hasConceptScore W2023778963C2776967927 @default.
- W2023778963 hasConceptScore W2023778963C2777975735 @default.
- W2023778963 hasConceptScore W2023778963C2780374374 @default.
- W2023778963 hasConceptScore W2023778963C2780708107 @default.
- W2023778963 hasConceptScore W2023778963C2781069245 @default.
- W2023778963 hasConceptScore W2023778963C41008148 @default.
- W2023778963 hasConceptScore W2023778963C43617362 @default.
- W2023778963 hasConceptScore W2023778963C71240020 @default.
- W2023778963 hasConceptScore W2023778963C71924100 @default.
- W2023778963 hasConceptScore W2023778963C98015330 @default.
- W2023778963 hasIssue "2" @default.
- W2023778963 hasLocation W20237789631 @default.
- W2023778963 hasOpenAccess W2023778963 @default.
- W2023778963 hasPrimaryLocation W20237789631 @default.
- W2023778963 hasRelatedWork W2034383588 @default.
- W2023778963 hasRelatedWork W2092714536 @default.
- W2023778963 hasRelatedWork W2167753431 @default.
- W2023778963 hasRelatedWork W2360371377 @default.
- W2023778963 hasRelatedWork W2388937023 @default.
- W2023778963 hasRelatedWork W2418501509 @default.
- W2023778963 hasRelatedWork W2890293173 @default.
- W2023778963 hasRelatedWork W4210517097 @default.
- W2023778963 hasRelatedWork W4293523039 @default.
- W2023778963 hasRelatedWork W2529598566 @default.
- W2023778963 hasVolume "4" @default.
- W2023778963 isParatext "false" @default.
- W2023778963 isRetracted "false" @default.
- W2023778963 magId "2023778963" @default.
- W2023778963 workType "article" @default.