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- W2023779833 abstract "Abstract Three-dimensional pharmacophore models were generated for RXR α receptor agonists using quantitative approach (CATALYST HypoRefine). One optimal pharmacophore model for selective RXR α agonists was determined through careful validation processes. The best quantitative model (Hypo-1) had four features and eight excluded volumes: three hydrophobic groups and one hydrogen bond receptor. The model was validated using a wide range of test molecules. It could predict agonist activity and identify highly potent molecules. The present results are valuable to discover and develop specific RXR α agonists with desired biological activities." @default.
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- W2023779833 date "2009-02-01" @default.
- W2023779833 modified "2023-09-26" @default.
- W2023779833 title "A three-dimensional pharmacophore model for RXRα agonists" @default.
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- W2023779833 doi "https://doi.org/10.1016/j.molstruc.2008.10.065" @default.
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