FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023781708> ?p ?o ?g. }

• W2023781708 endingPage "108" @default.
• W2023781708 startingPage "91" @default.
• W2023781708 abstract "This study investigates growth and the induction of progesterone-receptor synthesis in the immature (day 20–23) rat uterus after injection of different doses of 5α-dihydrotestosterone (DHT) and testosterone (T) in long- and short-acting injection vehicles. Moderate doses of T (300 μ/day in saline for 3 days) elicit uterine growth (ca. 250% of control) that is abolished by concomitant injections of antiandrogen (1 mg flutamide/day or 8 mg DIMP/day) but is unaffected by injections of antiestrogens (60 μg CI-628 or U11,100A/day). Uterine growth evoked by 17β-estradiol (3 μg/day for 3 days) is, however, only antagonized with the antiestrogens but not antiandrogens. Experiments employing whole uteri in vitro indicate that the specific nuclear uptake of 10−8 M [3H]T is markedly inhibited by the antiandrogens DIMP, flutamide and the hydroxylated flutamide metabolite (LACT) [LACT > DIMP > FLUT] while the antiestrogens CI-628 and U11,100A are ineffective. In contrast, the specific nuclear uptake of 10−8 M [3H]-estradiol is inhibited by only the antiestrogens and not antiandrogens. When very high (5 or 10 mg) doses of DHT are administered in an oil-containing injection vehicle, nuclear translocation and cytoplasmic depletion of the estrogen receptor does occur and a uterotrophic response is elicited which is resistant to antagonism by antiandrogen. Likewise, the DHT-stimulated increase in progesterone-receptor content is not decreased by concomitant antiandrogen. Similar 5 or 10 mg doses of DHT, administered in a water-soluble dimethylsulfoxide vehicle, show little estrogen-receptor movement and the DHT-induced uterine growth and induction of progesterone-receptor synthesis is almost completely eliminated with antiandrogen. Regardless of the degree of uterine growth stimulation, however, the androgens are poor stimulators of uterine progesterone-receptor synthesis compared with estradiol. These results indicate that androgens may interact with both the androgen- and estrogen-receptor systems in the uterus in inducing uterine growth and that the nature of the cellular mechanism i.e., whether the androgen- and/or estrogen-receptor system is involved, is dependent critically upon the in vivo dose of androgen and the mode of hormone administration." @default.
• W2023781708 created "2016-06-24" @default.
• W2023781708 creator A5057163074 @default.
• W2023781708 creator A5080531304 @default.
• W2023781708 date "1979-08-01" @default.
• W2023781708 modified "2023-10-11" @default.
• W2023781708 title "Androgen-uterine interactions: An assessment of androgen interaction with the testosterone- and estrogen-receptor systems and stimulation of uterine growth and progesterone-receptor synthesis" @default.
• W2023781708 cites W1565409229 @default.
• W2023781708 cites W1775749144 @default.
• W2023781708 cites W1968281428 @default.
• W2023781708 cites W1983649348 @default.
• W2023781708 cites W1985592076 @default.
• W2023781708 cites W2001613633 @default.
• W2023781708 cites W2007185356 @default.
• W2023781708 cites W2017391320 @default.
• W2023781708 cites W2018617566 @default.
• W2023781708 cites W2021120441 @default.
• W2023781708 cites W2024301305 @default.
• W2023781708 cites W2037739335 @default.
• W2023781708 cites W2044964819 @default.
• W2023781708 cites W2049137512 @default.
• W2023781708 cites W2055234332 @default.
• W2023781708 cites W2066504234 @default.
• W2023781708 cites W2072226999 @default.
• W2023781708 cites W2073817423 @default.
• W2023781708 cites W2077815818 @default.
• W2023781708 cites W2077857833 @default.
• W2023781708 cites W2079821441 @default.
• W2023781708 cites W2086800741 @default.
• W2023781708 cites W2093646053 @default.
• W2023781708 cites W2111648388 @default.
• W2023781708 cites W2146499969 @default.
• W2023781708 cites W2261816148 @default.
• W2023781708 cites W2415892632 @default.
• W2023781708 cites W59804398 @default.
• W2023781708 doi "https://doi.org/10.1016/0303-7207(79)90010-8" @default.
• W2023781708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/499651" @default.
• W2023781708 hasPublicationYear "1979" @default.
• W2023781708 type Work @default.
• W2023781708 sameAs 2023781708 @default.
• W2023781708 citedByCount "69" @default.
• W2023781708 countsByYear W20237817082012 @default.
• W2023781708 countsByYear W20237817082014 @default.
• W2023781708 countsByYear W20237817082015 @default.
• W2023781708 countsByYear W20237817082016 @default.
• W2023781708 countsByYear W20237817082017 @default.
• W2023781708 countsByYear W20237817082018 @default.
• W2023781708 countsByYear W20237817082019 @default.
• W2023781708 crossrefType "journal-article" @default.
• W2023781708 hasAuthorship W2023781708A5057163074 @default.
• W2023781708 hasAuthorship W2023781708A5080531304 @default.
• W2023781708 hasConcept C121608353 @default.
• W2023781708 hasConcept C126322002 @default.
• W2023781708 hasConcept C134018914 @default.
• W2023781708 hasConcept C185592680 @default.
• W2023781708 hasConcept C2776067312 @default.
• W2023781708 hasConcept C2777164284 @default.
• W2023781708 hasConcept C2777911890 @default.
• W2023781708 hasConcept C2778313021 @default.
• W2023781708 hasConcept C2779279991 @default.
• W2023781708 hasConcept C2779322244 @default.
• W2023781708 hasConcept C2779881493 @default.
• W2023781708 hasConcept C2780192828 @default.
• W2023781708 hasConcept C2910016293 @default.
• W2023781708 hasConcept C530470458 @default.
• W2023781708 hasConcept C61367390 @default.
• W2023781708 hasConcept C71315377 @default.
• W2023781708 hasConcept C71924100 @default.
• W2023781708 hasConcept C84606932 @default.
• W2023781708 hasConcept C86803240 @default.
• W2023781708 hasConcept C98717036 @default.
• W2023781708 hasConceptScore W2023781708C121608353 @default.
• W2023781708 hasConceptScore W2023781708C126322002 @default.
• W2023781708 hasConceptScore W2023781708C134018914 @default.
• W2023781708 hasConceptScore W2023781708C185592680 @default.
• W2023781708 hasConceptScore W2023781708C2776067312 @default.
• W2023781708 hasConceptScore W2023781708C2777164284 @default.
• W2023781708 hasConceptScore W2023781708C2777911890 @default.
• W2023781708 hasConceptScore W2023781708C2778313021 @default.
• W2023781708 hasConceptScore W2023781708C2779279991 @default.
• W2023781708 hasConceptScore W2023781708C2779322244 @default.
• W2023781708 hasConceptScore W2023781708C2779881493 @default.
• W2023781708 hasConceptScore W2023781708C2780192828 @default.
• W2023781708 hasConceptScore W2023781708C2910016293 @default.
• W2023781708 hasConceptScore W2023781708C530470458 @default.
• W2023781708 hasConceptScore W2023781708C61367390 @default.
• W2023781708 hasConceptScore W2023781708C71315377 @default.
• W2023781708 hasConceptScore W2023781708C71924100 @default.
• W2023781708 hasConceptScore W2023781708C84606932 @default.
• W2023781708 hasConceptScore W2023781708C86803240 @default.
• W2023781708 hasConceptScore W2023781708C98717036 @default.
• W2023781708 hasIssue "2" @default.
• W2023781708 hasLocation W20237817081 @default.
• W2023781708 hasLocation W20237817082 @default.
• W2023781708 hasOpenAccess W2023781708 @default.
• W2023781708 hasPrimaryLocation W20237817081 @default.
• W2023781708 hasRelatedWork W1970686039 @default.
• W2023781708 hasRelatedWork W1971000890 @default.

• next