Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023782352> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2023782352 abstract "Mitogen activated protein kinases (MAPKs) play a key role in cell proliferation, cell cycle progression and cell transformation, and activated Ras/ERKs/RSK2 signaling pathways have been widely identified in many solid tumors. In this study, we found that magnolin, a compound found in Magnolia species, directly targeted and inhibited ERK1 and ERK2 kinase activities with IC 50 values of 87 nM and 16.5 nM by competing with ATP in an active pocket, respectively. Further, we demonstrated that magnolin inhibited EGF-induced p90RSKs phopshorylation at Thr359/Ser363, but not ERKs phosphorylation at Thr202/Tyr204, resulted in inhibition of cell proliferation by suppression of G1/S cell cycle transition. Additionally, p38 kinases, Jun N-terminal kinases, and Akts did not involved magnolin-mediated inhibitory signaling. Magnolin targeting on ERK1 and 2 activities suppressed the phosphorylation of RSK2 and downstream target proteins including ATF1 and c-Jun and AP-1, a dimer of Jun/Fos, and the transactivation activities of ATF1 and AP-1. Notably, ERKs inhibition by magnolin suppressed EGF-induced anchorage-independent cell transformation and colony growth of Ras G12V - harboring A549 human lung cancer cells and NIH3T3 cells stably expressing Ras G12V in soft agar. Taken together, these results demonstrated that magnolin might be a naturally occurring chemoprevention and therapeutic agent capable of inhibiting cell proliferation and transformation by targeting ERK1 and ERK2. Citation Format: Cheol-Jung Lee, Mee-Hyun Lee, Ji-Young Lee, Ji Hong Song, Yong-Yeon Cho. ERK1/2 targeting with magnolin as a chemopreventive agent. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1249. doi:10.1158/1538-7445.AM2014-1249" @default.
- W2023782352 created "2016-06-24" @default.
- W2023782352 creator A5016743353 @default.
- W2023782352 creator A5080180259 @default.
- W2023782352 creator A5080891156 @default.
- W2023782352 creator A5083524882 @default.
- W2023782352 creator A5086033300 @default.
- W2023782352 date "2014-09-30" @default.
- W2023782352 modified "2023-10-17" @default.
- W2023782352 title "Abstract 1249: ERK1/2 targeting with magnolin as a chemopreventive agent" @default.
- W2023782352 doi "https://doi.org/10.1158/1538-7445.am2014-1249" @default.
- W2023782352 hasPublicationYear "2014" @default.
- W2023782352 type Work @default.
- W2023782352 sameAs 2023782352 @default.
- W2023782352 citedByCount "0" @default.
- W2023782352 crossrefType "proceedings-article" @default.
- W2023782352 hasAuthorship W2023782352A5016743353 @default.
- W2023782352 hasAuthorship W2023782352A5080180259 @default.
- W2023782352 hasAuthorship W2023782352A5080891156 @default.
- W2023782352 hasAuthorship W2023782352A5083524882 @default.
- W2023782352 hasAuthorship W2023782352A5086033300 @default.
- W2023782352 hasConcept C104317684 @default.
- W2023782352 hasConcept C11960822 @default.
- W2023782352 hasConcept C1292079 @default.
- W2023782352 hasConcept C1491633281 @default.
- W2023782352 hasConcept C184235292 @default.
- W2023782352 hasConcept C185592680 @default.
- W2023782352 hasConcept C29537977 @default.
- W2023782352 hasConcept C502942594 @default.
- W2023782352 hasConcept C55493867 @default.
- W2023782352 hasConcept C57074206 @default.
- W2023782352 hasConcept C62112901 @default.
- W2023782352 hasConcept C86339819 @default.
- W2023782352 hasConcept C86803240 @default.
- W2023782352 hasConcept C95444343 @default.
- W2023782352 hasConceptScore W2023782352C104317684 @default.
- W2023782352 hasConceptScore W2023782352C11960822 @default.
- W2023782352 hasConceptScore W2023782352C1292079 @default.
- W2023782352 hasConceptScore W2023782352C1491633281 @default.
- W2023782352 hasConceptScore W2023782352C184235292 @default.
- W2023782352 hasConceptScore W2023782352C185592680 @default.
- W2023782352 hasConceptScore W2023782352C29537977 @default.
- W2023782352 hasConceptScore W2023782352C502942594 @default.
- W2023782352 hasConceptScore W2023782352C55493867 @default.
- W2023782352 hasConceptScore W2023782352C57074206 @default.
- W2023782352 hasConceptScore W2023782352C62112901 @default.
- W2023782352 hasConceptScore W2023782352C86339819 @default.
- W2023782352 hasConceptScore W2023782352C86803240 @default.
- W2023782352 hasConceptScore W2023782352C95444343 @default.
- W2023782352 hasLocation W20237823521 @default.
- W2023782352 hasOpenAccess W2023782352 @default.
- W2023782352 hasPrimaryLocation W20237823521 @default.
- W2023782352 hasRelatedWork W1970465585 @default.
- W2023782352 hasRelatedWork W1980990713 @default.
- W2023782352 hasRelatedWork W1989855597 @default.
- W2023782352 hasRelatedWork W2005930676 @default.
- W2023782352 hasRelatedWork W2040782655 @default.
- W2023782352 hasRelatedWork W2073030463 @default.
- W2023782352 hasRelatedWork W2099216474 @default.
- W2023782352 hasRelatedWork W2149665901 @default.
- W2023782352 hasRelatedWork W2158826674 @default.
- W2023782352 hasRelatedWork W2165039236 @default.
- W2023782352 hasRelatedWork W2213586441 @default.
- W2023782352 hasRelatedWork W2477229438 @default.
- W2023782352 hasRelatedWork W2527491445 @default.
- W2023782352 hasRelatedWork W2587656837 @default.
- W2023782352 hasRelatedWork W2787684716 @default.
- W2023782352 hasRelatedWork W2886703892 @default.
- W2023782352 hasRelatedWork W2887712539 @default.
- W2023782352 hasRelatedWork W2981594832 @default.
- W2023782352 hasRelatedWork W2998948414 @default.
- W2023782352 hasRelatedWork W3156188897 @default.
- W2023782352 isParatext "false" @default.
- W2023782352 isRetracted "false" @default.
- W2023782352 magId "2023782352" @default.
- W2023782352 workType "article" @default.