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- W2023784162 abstract "Interference with myelin deposition and brain growth was produced in rats by administering p-chlorophenylalanine (PCPA), alone or with phenylalanine (PHE), from the fifth postnatal day. Treatment with PCPA + PHE until 20 days of age resulted in significantly greater developmental impairment than that produced by PCPA alone. The extent of the maturational arrest was reflected in a corresponding failure to achieve the progressive latency decrements observed in the brain stem evoked potentials of normally maturing animals. In rats treated until 30 days of age the metabolic and electrophysiologic abnormalities were attenuated. Synaptosomal content at either age and under both experimental conditions did not appear to differ from that of the control brains. Rats which received PCPA or PCPA + PHE for a brief period later in development (from 17 to 20 days of age) maintained relatively normal myelin deposition and brain growth. The latencies of their brain stem evoked potentials also remained normal despite the presence of low cerebral serotonin concentrations. These data suggst that this latency provides a general measure of brain development which seems particularly sensitive to changes in the rate of myelination." @default.
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- W2023784162 title "Latency changes in brain stem auditory evoked potentials associated with impaired brain myelination" @default.
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- W2023784162 doi "https://doi.org/10.1016/0014-4886(78)90126-7" @default.
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