Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023784682> ?p ?o ?g. }
- W2023784682 endingPage "1909" @default.
- W2023784682 startingPage "1899" @default.
- W2023784682 abstract "Stardust (Sdt) and Discs-Large (Dlg) are membrane-associated guanylate kinases (MAGUKs) involved in the organization of supramolecular protein complexes at distinct epithelial membrane compartments in Drosophila. Loss of either Sdt or Dlg affects epithelial development with severe effects on apico-basal polarity. Moreover, Dlg is required for the structural and functional integrity of synaptic junctions. Recent biochemical and cell culture studies have revealed that various mammalian MAGUKs can interact with mLin-7/Veli/MALS, a small PDZ-domain protein. To substantiate these findings for their in vivo significance with regard to Sdt- and Dlg-based protein complexes, we analyzed the subcellular distribution of Drosophila Lin-7 (DLin-7) and performed genetic and biochemical assays to characterize its interaction with either of the two MAGUKs. In epithelia, Sdt mediates the recruitment of DLin-7 to the subapical region, while at larval neuromuscular junctions, a particular isoform of Dlg, Dlg-S97, is required for postsynaptic localization of DLin-7. Ectopic expression of Dlg-S97 in epithelia, however, was not sufficient to induce a redistribution of DLin-7. These results imply that the recruitment of DLin-7 to MAGUK-based protein complexes is defined by cell-type specific mechanisms and that DLin-7 acts downstream of Sdt in epithelia and downstream of Dlg at synapses." @default.
- W2023784682 created "2016-06-24" @default.
- W2023784682 creator A5002595262 @default.
- W2023784682 creator A5008631938 @default.
- W2023784682 creator A5025582716 @default.
- W2023784682 creator A5035912270 @default.
- W2023784682 creator A5039810760 @default.
- W2023784682 creator A5040229050 @default.
- W2023784682 creator A5041839079 @default.
- W2023784682 date "2004-04-15" @default.
- W2023784682 modified "2023-09-26" @default.
- W2023784682 title "Cell type-specific recruitment of<i>Drosophila</i>Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97" @default.
- W2023784682 cites W121356167 @default.
- W2023784682 cites W1535112832 @default.
- W2023784682 cites W1624178692 @default.
- W2023784682 cites W1640649913 @default.
- W2023784682 cites W1893184536 @default.
- W2023784682 cites W1936080787 @default.
- W2023784682 cites W1975306052 @default.
- W2023784682 cites W1976577398 @default.
- W2023784682 cites W1976733068 @default.
- W2023784682 cites W1978044509 @default.
- W2023784682 cites W1978552369 @default.
- W2023784682 cites W1979026763 @default.
- W2023784682 cites W1979333716 @default.
- W2023784682 cites W1980398528 @default.
- W2023784682 cites W1995136282 @default.
- W2023784682 cites W2001443072 @default.
- W2023784682 cites W2007239691 @default.
- W2023784682 cites W2013054583 @default.
- W2023784682 cites W2018581402 @default.
- W2023784682 cites W2021859563 @default.
- W2023784682 cites W2034696312 @default.
- W2023784682 cites W2039378730 @default.
- W2023784682 cites W2043685409 @default.
- W2023784682 cites W2048443355 @default.
- W2023784682 cites W2048529602 @default.
- W2023784682 cites W2053108820 @default.
- W2023784682 cites W2054696788 @default.
- W2023784682 cites W2062975849 @default.
- W2023784682 cites W2066562134 @default.
- W2023784682 cites W2069017351 @default.
- W2023784682 cites W2083609148 @default.
- W2023784682 cites W2090948229 @default.
- W2023784682 cites W2091738825 @default.
- W2023784682 cites W2100350999 @default.
- W2023784682 cites W2101625485 @default.
- W2023784682 cites W2103205098 @default.
- W2023784682 cites W2104008077 @default.
- W2023784682 cites W2105006060 @default.
- W2023784682 cites W2108836535 @default.
- W2023784682 cites W2110185047 @default.
- W2023784682 cites W2110514104 @default.
- W2023784682 cites W2110643873 @default.
- W2023784682 cites W2114544196 @default.
- W2023784682 cites W2114871465 @default.
- W2023784682 cites W2128368447 @default.
- W2023784682 cites W2128703002 @default.
- W2023784682 cites W2133862855 @default.
- W2023784682 cites W2134939710 @default.
- W2023784682 cites W2147677686 @default.
- W2023784682 cites W2149011316 @default.
- W2023784682 cites W2156665864 @default.
- W2023784682 cites W2156874028 @default.
- W2023784682 cites W2156999424 @default.
- W2023784682 cites W2163043134 @default.
- W2023784682 cites W2165324125 @default.
- W2023784682 cites W2167834911 @default.
- W2023784682 cites W2168029064 @default.
- W2023784682 cites W2182359301 @default.
- W2023784682 cites W2297164003 @default.
- W2023784682 cites W2322458632 @default.
- W2023784682 doi "https://doi.org/10.1242/jcs.01029" @default.
- W2023784682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15039455" @default.
- W2023784682 hasPublicationYear "2004" @default.
- W2023784682 type Work @default.
- W2023784682 sameAs 2023784682 @default.
- W2023784682 citedByCount "64" @default.
- W2023784682 countsByYear W20237846822012 @default.
- W2023784682 countsByYear W20237846822013 @default.
- W2023784682 countsByYear W20237846822014 @default.
- W2023784682 countsByYear W20237846822015 @default.
- W2023784682 countsByYear W20237846822016 @default.
- W2023784682 countsByYear W20237846822017 @default.
- W2023784682 countsByYear W20237846822020 @default.
- W2023784682 countsByYear W20237846822021 @default.
- W2023784682 countsByYear W20237846822022 @default.
- W2023784682 crossrefType "journal-article" @default.
- W2023784682 hasAuthorship W2023784682A5002595262 @default.
- W2023784682 hasAuthorship W2023784682A5008631938 @default.
- W2023784682 hasAuthorship W2023784682A5025582716 @default.
- W2023784682 hasAuthorship W2023784682A5035912270 @default.
- W2023784682 hasAuthorship W2023784682A5039810760 @default.
- W2023784682 hasAuthorship W2023784682A5040229050 @default.
- W2023784682 hasAuthorship W2023784682A5041839079 @default.
- W2023784682 hasConcept C104317684 @default.
- W2023784682 hasConcept C118322738 @default.
- W2023784682 hasConcept C144647389 @default.