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- W2023784880 abstract "Abstract Leucine oxidation was increased and its incorporation into protein decreased in incubated hemidiaphragms from rats bearing a Walker 256 carcinoma. Homogenates of diaphragms from these rats exhibited a moderate increase in branchedchain oxo-acid dehydrogenase activity but no change in leucine aminotransferase. Hemidiaphragms of tumour-bearing rats incubated with 0.1 mM leucine showed a decreased release of alanine, no alteration in glutamine release, and an increased output of ammonia. When glucose was added to the medium, leucine oxidation was still increased in hemidiaphragms of tumour-bearing rats, alanine release increased but only to control levels, ammonia release decreased and glutamine release remained at control levels. It was concluded that the increased leucine oxidation accompanying increased net protein breakdown in the tumour-bearing animal is not providing an increase in the output of gluconeogenic precursors." @default.
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- W2023784880 date "1980-09-01" @default.
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- W2023784880 title "Leucine metabolism in skeletal muscle of the tumour-bearing rat" @default.
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- W2023784880 doi "https://doi.org/10.1016/0014-2964(80)90174-7" @default.
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