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- W2023785226 abstract "Biological systems are modular, and this modularity evolves over time and in different environments. A number of observations have been made of increased modularity in biological systems under increased environmental pressure. We here develop a quasispecies theory for the dynamics of modularity in populations of these systems. We show how the steady-state fitness in a randomly changing environment can be computed. We derive a fluctuation dissipation relation for the rate of change of modularity and use it to derive a relationship between rate of environmental changes and rate of growth of modularity. We also find a principle of least action for the evolved modularity at steady state. Finally, we compare our predictions to simulations of protein evolution and find them to be consistent." @default.
- W2023785226 created "2016-06-24" @default.
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- W2023785226 date "2015-01-28" @default.
- W2023785226 modified "2023-09-24" @default.
- W2023785226 title "Quasispecies theory for evolution of modularity" @default.
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- W2023785226 doi "https://doi.org/10.1103/physreve.91.012714" @default.
- W2023785226 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4477872" @default.
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