FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023785540> ?p ?o ?g. }

• W2023785540 endingPage "e29286" @default.
• W2023785540 startingPage "e29286" @default.
• W2023785540 abstract "Fine mapping of human cytotoxic T lymphocyte (CTL) responses against hepatitis C virus (HCV) is based on external loading of target cells with synthetic peptides which are either derived from prediction algorithms or from overlapping peptide libraries. These strategies do not address putative host and viral mechanisms which may alter processing as well as presentation of CTL epitopes. Therefore, the aim of this proof-of-concept study was to identify naturally processed HCV-derived major histocompatibility complex (MHC) class I ligands. To this end, continuous human cell lines were engineered to inducibly express HCV proteins and to constitutively express high levels of functional HLA-A2. These cell lines were recognized in an HLA-A2-restricted manner by HCV-specific CTLs. Ligands eluted from HLA-A2 molecules isolated from large-scale cultures of these cell lines were separated by high performance liquid chromatography and further analyzed by electrospray ionization quadrupole time of flight mass spectrometry (MS)/tandem MS. These analyses allowed the identification of two HLA-A2-restricted epitopes derived from HCV nonstructural proteins (NS) 3 and 5B (NS3₁₄₀₆₋₁₄₁₅ and NS5B₂₅₉₄₋₂₆₀₂). In conclusion, we describe a general strategy that may be useful to investigate HCV pathogenesis and may contribute to the development of preventive and therapeutic vaccines in the future." @default.
• W2023785540 created "2016-06-24" @default.
• W2023785540 creator A5012626247 @default.
• W2023785540 creator A5023755077 @default.
• W2023785540 creator A5034549158 @default.
• W2023785540 creator A5035871318 @default.
• W2023785540 creator A5037546703 @default.
• W2023785540 creator A5042161524 @default.
• W2023785540 creator A5072444698 @default.
• W2023785540 creator A5086328131 @default.
• W2023785540 creator A5090153362 @default.
• W2023785540 creator A5091273319 @default.
• W2023785540 date "2012-01-03" @default.
• W2023785540 modified "2023-10-16" @default.
• W2023785540 title "Identification of Naturally Processed Hepatitis C Virus-Derived Major Histocompatibility Complex Class I Ligands" @default.
• W2023785540 cites W1572895514 @default.
• W2023785540 cites W1977677882 @default.
• W2023785540 cites W1985680307 @default.
• W2023785540 cites W2001450540 @default.
• W2023785540 cites W2022239954 @default.
• W2023785540 cites W2048319398 @default.
• W2023785540 cites W2052014046 @default.
• W2023785540 cites W2054929375 @default.
• W2023785540 cites W2056374390 @default.
• W2023785540 cites W2059530064 @default.
• W2023785540 cites W2071911570 @default.
• W2023785540 cites W2078937761 @default.
• W2023785540 cites W2102903170 @default.
• W2023785540 cites W2111359040 @default.
• W2023785540 cites W2121037457 @default.
• W2023785540 cites W2130259551 @default.
• W2023785540 cites W2146283116 @default.
• W2023785540 cites W2153346747 @default.
• W2023785540 cites W2153899387 @default.
• W2023785540 cites W2154915093 @default.
• W2023785540 cites W4249994795 @default.
• W2023785540 doi "https://doi.org/10.1371/journal.pone.0029286" @default.
• W2023785540 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3250420" @default.
• W2023785540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22235280" @default.
• W2023785540 hasPublicationYear "2012" @default.
• W2023785540 type Work @default.
• W2023785540 sameAs 2023785540 @default.
• W2023785540 citedByCount "14" @default.
• W2023785540 countsByYear W20237855402013 @default.
• W2023785540 countsByYear W20237855402014 @default.
• W2023785540 countsByYear W20237855402015 @default.
• W2023785540 countsByYear W20237855402018 @default.
• W2023785540 countsByYear W20237855402019 @default.
• W2023785540 countsByYear W20237855402020 @default.
• W2023785540 countsByYear W20237855402022 @default.
• W2023785540 countsByYear W20237855402023 @default.
• W2023785540 crossrefType "journal-article" @default.
• W2023785540 hasAuthorship W2023785540A5012626247 @default.
• W2023785540 hasAuthorship W2023785540A5023755077 @default.
• W2023785540 hasAuthorship W2023785540A5034549158 @default.
• W2023785540 hasAuthorship W2023785540A5035871318 @default.
• W2023785540 hasAuthorship W2023785540A5037546703 @default.
• W2023785540 hasAuthorship W2023785540A5042161524 @default.
• W2023785540 hasAuthorship W2023785540A5072444698 @default.
• W2023785540 hasAuthorship W2023785540A5086328131 @default.
• W2023785540 hasAuthorship W2023785540A5090153362 @default.
• W2023785540 hasAuthorship W2023785540A5091273319 @default.
• W2023785540 hasBestOaLocation W20237855401 @default.
• W2023785540 hasConcept C108249834 @default.
• W2023785540 hasConcept C147483822 @default.
• W2023785540 hasConcept C147969180 @default.
• W2023785540 hasConcept C159047783 @default.
• W2023785540 hasConcept C167672396 @default.
• W2023785540 hasConcept C170627219 @default.
• W2023785540 hasConcept C188280979 @default.
• W2023785540 hasConcept C195616568 @default.
• W2023785540 hasConcept C203014093 @default.
• W2023785540 hasConcept C207936829 @default.
• W2023785540 hasConcept C2522874641 @default.
• W2023785540 hasConcept C2776408679 @default.
• W2023785540 hasConcept C70721500 @default.
• W2023785540 hasConcept C86803240 @default.
• W2023785540 hasConceptScore W2023785540C108249834 @default.
• W2023785540 hasConceptScore W2023785540C147483822 @default.
• W2023785540 hasConceptScore W2023785540C147969180 @default.
• W2023785540 hasConceptScore W2023785540C159047783 @default.
• W2023785540 hasConceptScore W2023785540C167672396 @default.
• W2023785540 hasConceptScore W2023785540C170627219 @default.
• W2023785540 hasConceptScore W2023785540C188280979 @default.
• W2023785540 hasConceptScore W2023785540C195616568 @default.
• W2023785540 hasConceptScore W2023785540C203014093 @default.
• W2023785540 hasConceptScore W2023785540C207936829 @default.
• W2023785540 hasConceptScore W2023785540C2522874641 @default.
• W2023785540 hasConceptScore W2023785540C2776408679 @default.
• W2023785540 hasConceptScore W2023785540C70721500 @default.
• W2023785540 hasConceptScore W2023785540C86803240 @default.
• W2023785540 hasIssue "1" @default.
• W2023785540 hasLocation W20237855401 @default.
• W2023785540 hasLocation W20237855402 @default.
• W2023785540 hasLocation W20237855403 @default.
• W2023785540 hasLocation W20237855404 @default.
• W2023785540 hasLocation W20237855405 @default.
• W2023785540 hasLocation W20237855406 @default.

• next