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- W2023787395 abstract "30 patients with disorders of calcium metabolism were treated with dichloromethylene diphosphonate (Cl2MDP, or clodronate disodium), an inhibitor of bone resorption. 13 patients with Paget's disease of bone were given Cl2MDP by mouth (1·6 g/day). Serum-alkaline-phosphatase and urinary hydroxyproline fell to normal or near-normal within 3-7 months, and there was a clinical improvement in all but 1 patient. Cl2MDP (0·8-3·2 g/day) also reduced plasma-calcium and urinary calcium in 17 patients with hypercalcæmia due to primary hyperparathyroidism or secondary to malignant disease. Cl2MDP seems to be an effective oral drug for inhibiting excessive bone resorption in man." @default.
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- W2023787395 date "1980-05-01" @default.
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- W2023787395 title "EFFECT OF DICHLOROMETHYLENE DIPHOSPHONATE IN PAGET'S DISEASE OF BONE AND IN HYPERCALCÆMIA DUE TO PRIMARY HYPERPARATHYROIDISM OR MALIGNANT DISEASE" @default.
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- W2023787395 doi "https://doi.org/10.1016/s0140-6736(80)91496-8" @default.
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