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- W2023792186 abstract "The sorption of diazepam, nitroglycerin, and warfarin sodium to a new polypropylene-lined infusion bag (Softbag) was studied. For comparison, the loss of the same drugs was measured in two other types of containers. Clinical amounts of the drugs were added to 100 ml of 0.9% sodium chloride infusion solution in glass bottles, polyvinyl chloride (PVC) bags, and Softbag containers composed of inner and outer layers of polypropylene and a middle layer of a polypropylene-based elastomeric alloy. The containers were stored at room temperature (21 ± 2°C) without protection from light for 24 h (diazepam) and 120 h (nitroglycerin and warfarin sodium). Samples were taken at various intervals and assayed for drug concentration by UV spectrophotometry and/or high-performance liquid chromatography (HPLC). UV spectrophotometry was the primary method for diazepam and warfarin sodium whereas nitroglycerin was assayed only by HPLC. There were no appreciable changes in pH after 24 or 120 h and all the admixtures remained clear and colorless. Diazepam, nitroglycerin, and warfarin sodium did not show any sorption to glass bottles or Softbag containers. In PVC bags, however, up to 70% of diazepam was lost after 24 h, and 75% of nitroglycerin and 70% of warfarin sodium were sorbed after 120 h when the pH of the solution was 4.9. The sorption of warfarin sodium was only 30% when the pH of the solution was 5.6. There was no sign of extra peaks of degradation products in the chromatograms of the compounds and the purity of the Chromatographie peaks was evident when studied by HPLC with a diode array detector." @default.
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- W2023792186 date "1994-09-01" @default.
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- W2023792186 title "Sorptive loss of diazepam, nitroglycerin and warfarin sodium to polypropylene-lined infusion bags (Softbags)" @default.
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- W2023792186 doi "https://doi.org/10.1016/0378-5173(94)90158-9" @default.
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